Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4663045..4663561 Replicon chromosome
Accession NZ_CP056216
Organism Klebsiella pneumoniae strain RHBSTW-00982

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag HV343_RS22775 Protein ID WP_004192395.1
Coordinates 4663045..4663329 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag HV343_RS22780 Protein ID WP_004192397.1
Coordinates 4663319..4663561 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV343_RS22750 4658462..4658770 - 309 WP_004192389.1 PTS sugar transporter subunit IIB -
HV343_RS22755 4658855..4659028 + 174 WP_002886906.1 hypothetical protein -
HV343_RS22760 4659031..4659774 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HV343_RS22765 4660131..4662269 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HV343_RS22770 4662577..4663041 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HV343_RS22775 4663045..4663329 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV343_RS22780 4663319..4663561 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV343_RS22785 4663639..4665549 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HV343_RS22790 4665572..4666726 - 1155 WP_004178372.1 lactonase family protein -
HV343_RS22795 4666793..4667533 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T163005 WP_004192395.1 NZ_CP056216:c4663329-4663045 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T163005 NZ_CP072265:c5029960-5029826 [Xanthomonas citri pv. glycines]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGTTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT163005 WP_004192397.1 NZ_CP056216:c4663561-4663319 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT163005 NZ_CP072265:c5030187-5030035 [Xanthomonas citri pv. glycines]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References