Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4576737..4577407 Replicon chromosome
Accession NZ_CP056216
Organism Klebsiella pneumoniae strain RHBSTW-00982

Toxin (Protein)


Gene name ypjF Uniprot ID A0A483GLH7
Locus tag HV343_RS22385 Protein ID WP_023301398.1
Coordinates 4576737..4577069 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A483GII7
Locus tag HV343_RS22390 Protein ID WP_023301397.1
Coordinates 4577090..4577407 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV343_RS22360 4571962..4572634 + 673 Protein_4381 DUF4400 domain-containing protein -
HV343_RS22365 4572645..4573529 + 885 WP_004192285.1 RES domain-containing protein -
HV343_RS22370 4573728..4573916 - 189 Protein_4383 transposase -
HV343_RS22375 4573933..4575044 - 1112 Protein_4384 IS3 family transposase -
HV343_RS22380 4575443..4576303 - 861 WP_023301399.1 hypothetical protein -
HV343_RS22385 4576737..4577069 - 333 WP_023301398.1 TA system toxin CbtA family protein Toxin
HV343_RS22390 4577090..4577407 - 318 WP_023301397.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV343_RS22395 4577426..4577647 - 222 WP_023301396.1 DUF987 domain-containing protein -
HV343_RS22400 4577656..4578138 - 483 WP_023301395.1 RadC family protein -
HV343_RS22405 4578147..4578605 - 459 WP_023301394.1 antirestriction protein -
HV343_RS22410 4578691..4578927 - 237 WP_032446575.1 DUF905 domain-containing protein -
HV343_RS22415 4579005..4579415 - 411 WP_023301393.1 hypothetical protein -
HV343_RS22420 4579482..4579919 - 438 WP_023301392.1 hypothetical protein -
HV343_RS22425 4579961..4580497 - 537 WP_023301391.1 DUF4339 domain-containing protein -
HV343_RS22430 4580523..4581233 - 711 WP_023301390.1 DeoR family transcriptional regulator -
HV343_RS22435 4581442..4582266 - 825 WP_023301389.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-101)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12610.65 Da        Isoelectric Point: 5.6692

>T163004 WP_023301398.1 NZ_CP056216:c4577069-4576737 [Klebsiella pneumoniae]
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM

Download         Length: 333 bp

>T163004 NZ_CP072265:99562-99840 [Xanthomonas citri pv. glycines]
GTGCCGGCATTGGCTGATCTGGACGCAATTGCCGACTACATCGCAATCGATAACGCACCCGCTGCAGCGGCGCTGGTGAA
ACGGGTGTTCGCGCACGTTGAGCAATTGATCGAACACCCGGACAGCGGAAGCCGACCACAGGAACTCAAGCGCTCGCGCT
ATCGCCAGATTGTCGAACCACCTTGCCGCGTGTTCTACCGCGTGGATGGGCAGCGCATCGTGGTGGTGCACATCATGCGG
TCGGAGCGCGCGCTTCGCGGGAACCGTCTTTCACGCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11785.37 Da        Isoelectric Point: 6.6277

>AT163004 WP_023301397.1 NZ_CP056216:c4577407-4577090 [Klebsiella pneumoniae]
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR

Download         Length: 318 bp

>AT163004 NZ_CP072265:99296-99553 [Xanthomonas citri pv. glycines]
ATGCGCACCGAACTTGTCACCACGCTCAAGCGTCAGGCGACCGAACTCCTTGCAGCTGCAGAGCGCGACAAGGAGCCAAT
CCTGATCACACAGCACGGTTTACCCAGTGCCTATCTGGTGGATGTTGCCAGCTATGAGCGCATGCAGCAGCGCATTGCGC
TCCTCGAAGGAATCGCCCGTGGAGAAATGGCAGTCGCGGAAGGCCGTACGCTGAGCCATGAACAGGCACGGCAACGCATG
GCGCGATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A483GII7

References