Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 808567..809224 Replicon chromosome
Accession NZ_CP056216
Organism Klebsiella pneumoniae strain RHBSTW-00982

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HV343_RS04015 Protein ID WP_002916310.1
Coordinates 808814..809224 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HV343_RS04010 Protein ID WP_002916312.1
Coordinates 808567..808833 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV343_RS03985 803723..805156 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HV343_RS03990 805275..806003 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HV343_RS03995 806053..806364 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HV343_RS04000 806528..807187 + 660 WP_002916317.1 hemolysin III family protein -
HV343_RS04005 807338..808321 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HV343_RS04010 808567..808833 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HV343_RS04015 808814..809224 + 411 WP_002916310.1 protein YgfX Toxin
HV343_RS04020 809231..809752 - 522 WP_002916308.1 flavodoxin FldB -
HV343_RS04025 809853..810749 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HV343_RS04030 810772..811485 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV343_RS04035 811491..813224 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T162991 WP_002916310.1 NZ_CP056216:808814-809224 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T162991 NZ_CP072209:c21976-21695 [Streptomyces fradiae]
GTGGGGTACGTCACGCGCTTCACGCCCCACGCGCAGCGCGACATGCTCAAGGTCCCGCGCCCGGACGCCCTGCGCATCCT
GTACCGCCTCGCCGAGTTGCAGAAGGCCATCGACGGAGGCGACACCACGGCGTTCGACATCAAAGCCCTGCGGAGCCACC
ATGCCCGCTGGCGGCTCAGGGTCGGTGACTACCGCGTCGTCTACACCGTCGAGGACGGCCAGTTGATCGTGTGGGTCCTG
GCCGTTGGTAACCGGCGCGAGGTCTACCGGCAGATTCCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT162991 WP_002916312.1 NZ_CP056216:808567-808833 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT162991 NZ_CP072209:c22261-21980 [Streptomyces fradiae]
ATGAGTGAGCCGATCGTCGAATCAATGGCCGAGGTCCGCAGTCACCTGGCCGACGTCATCGACCGTGCCCGCCGGGAGGA
GACTCCGACGATCATCACCCGGCGCGGCAAGCAGGAAGCCGTCGTGATCGACATCGAGGAGTACCAGCGGCTGCGCCGTC
TCGCCGAGGACGCCGAGGAGGCATGGCTCAACCGGCTGGCCGACGAGGCCGAGTCGGAGGGCACGCGAGGGTCGGTCTCG
CTCGAAGAGATGGCCGCCCTCCTTCGTACCGATCAGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References