Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4235956..4236483 Replicon chromosome
Accession NZ_CP056200
Organism Citrobacter sp. RHBSTW-00986

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HV345_RS20450 Protein ID WP_181636000.1
Coordinates 4235956..4236231 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HV345_RS20455 Protein ID WP_094760973.1
Coordinates 4236235..4236483 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV345_RS20420 4232055..4232417 + 363 WP_181635997.1 endoribonuclease SymE -
HV345_RS20425 4232480..4232965 - 486 WP_016151545.1 type VI secretion system tube protein Hcp -
HV345_RS20430 4232984..4233310 - 327 WP_016151544.1 DUF1493 family protein -
HV345_RS20435 4233304..4233753 - 450 WP_003830103.1 hypothetical protein -
HV345_RS20440 4234012..4234884 + 873 WP_181635998.1 HNH endonuclease -
HV345_RS20445 4235044..4235841 - 798 WP_181635999.1 helix-turn-helix transcriptional regulator -
HV345_RS20450 4235956..4236231 - 276 WP_181636000.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV345_RS20455 4236235..4236483 - 249 WP_094760973.1 ribbon-helix-helix domain-containing protein Antitoxin
HV345_RS20460 4236560..4237393 - 834 WP_181636001.1 DUF4942 domain-containing protein -
HV345_RS20465 4237509..4237850 - 342 WP_181506237.1 TA system toxin CbtA family protein -
HV345_RS20470 4237906..4238139 - 234 WP_181506238.1 hypothetical protein -
HV345_RS20475 4238136..4238489 - 354 WP_181506239.1 type IV toxin-antitoxin system YeeU family antitoxin -
HV345_RS20480 4238535..4238756 - 222 WP_181506240.1 DUF987 family protein -
HV345_RS20485 4238753..4239262 - 510 WP_181506241.1 DNA repair protein RadC -
HV345_RS20490 4239275..4239694 - 420 WP_181507050.1 antirestriction protein -
HV345_RS20495 4239810..4240628 - 819 WP_181506242.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4233304..4243056 9752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10968.38 Da        Isoelectric Point: 5.5735

>T162983 WP_181636000.1 NZ_CP056200:c4236231-4235956 [Citrobacter sp. RHBSTW-00986]
MEIYWTLKAQDDLERIYRFALQYSRQHADNVLDRLIIGCAGLTAHPAIGVQQTRYEPREVRKVLFDDYEVHYELRGNDIY
IVDLWHTKEER

Download         Length: 276 bp

>T162983 NZ_CP072204:2761168-2761275 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8987.33 Da        Isoelectric Point: 8.8294

>AT162983 WP_094760973.1 NZ_CP056200:c4236483-4236235 [Citrobacter sp. RHBSTW-00986]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSNMVDFANRLK
KA

Download         Length: 249 bp

>AT162983 NZ_CP072204:c2761115-2761054 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References