Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 1196167..1196834 | Replicon | chromosome |
| Accession | NZ_CP056200 | ||
| Organism | Citrobacter sp. RHBSTW-00986 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A156PNF2 |
| Locus tag | HV345_RS05860 | Protein ID | WP_001618791.1 |
| Coordinates | 1196167..1196496 (-) | Length | 110 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A156PNH9 |
| Locus tag | HV345_RS05865 | Protein ID | WP_001618790.1 |
| Coordinates | 1196517..1196834 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV345_RS05840 | 1192083..1193501 | - | 1419 | WP_181636687.1 | Na+/H+ antiporter NhaC | - |
| HV345_RS05845 | 1193545..1194513 | - | 969 | WP_077483231.1 | IS5 family transposase | - |
| HV345_RS05850 | 1194653..1195399 | + | 747 | WP_181636373.1 | SDR family oxidoreductase | - |
| HV345_RS05855 | 1195590..1195772 | - | 183 | WP_049271027.1 | hypothetical protein | - |
| HV345_RS05860 | 1196167..1196496 | - | 330 | WP_001618791.1 | TA system toxin CbtA family protein | Toxin |
| HV345_RS05865 | 1196517..1196834 | - | 318 | WP_001618790.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HV345_RS05870 | 1196853..1197074 | - | 222 | WP_001618789.1 | DUF987 domain-containing protein | - |
| HV345_RS05875 | 1197083..1197559 | - | 477 | WP_181636374.1 | RadC family protein | - |
| HV345_RS05880 | 1197575..1198033 | - | 459 | WP_000211838.1 | antirestriction protein | - |
| HV345_RS05885 | 1198131..1198370 | - | 240 | WP_000194654.1 | DUF905 domain-containing protein | - |
| HV345_RS05890 | 1198447..1198914 | - | 468 | WP_001547765.1 | hypothetical protein | - |
| HV345_RS05895 | 1198937..1199380 | - | 444 | WP_001547764.1 | phage transcriptional regulator | - |
| HV345_RS05900 | 1199380..1199616 | - | 237 | WP_001144031.1 | hypothetical protein | - |
| HV345_RS05905 | 1199657..1200358 | - | 702 | WP_001581462.1 | WYL domain-containing protein | - |
| HV345_RS05910 | 1200575..1201396 | - | 822 | WP_001548153.1 | DUF945 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1189996..1235474 | 45478 | |
| - | flank | IS/Tn | - | - | 1193545..1194513 | 968 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12509.43 Da Isoelectric Point: 7.2767
>T162972 WP_001618791.1 NZ_CP056200:c1196496-1196167 [Citrobacter sp. RHBSTW-00986]
MNTLPATTQRAAKPCLSPVAVWKMLLTHLLEQHYGLTLNDTPFSEERVIQEHIDAGITLADTVNFLVEKYELVRIDRKGF
SWQEQTPYISVVDILRARRSTDLLKTNVK
MNTLPATTQRAAKPCLSPVAVWKMLLTHLLEQHYGLTLNDTPFSEERVIQEHIDAGITLADTVNFLVEKYELVRIDRKGF
SWQEQTPYISVVDILRARRSTDLLKTNVK
Download Length: 330 bp
>T162972 NZ_CP072204:c595027-594563 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11905.54 Da Isoelectric Point: 7.3234
>AT162972 WP_001618790.1 NZ_CP056200:c1196834-1196517 [Citrobacter sp. RHBSTW-00986]
MSNITWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDAECRKLDETFPHFIRQMESMLTTGEVSPQHAHCVILYH
NGFTCEADTLGSCGYVYIAIYPTQR
MSNITWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDAECRKLDETFPHFIRQMESMLTTGEVSPQHAHCVILYH
NGFTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT162972 NZ_CP072204:c595362-595027 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A156PNF2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A156PNH9 |