Detailed information of TA system TA162958

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2286354..2287930
• Replicon: chromosome
• Accession: NZ_CP056199
• Organism: Enterobacter sp. RHBSTW-00994

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HV346_RS10995
• Protein ID: WP_181623516.1
• Coordinates: 2286623..2287930 (+)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HV346_RS10990
• Protein ID: WP_181623515.1
• Coordinates: 2286354..2286623 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV346_RS10960	2281570..2282154	-	585	WP_181623509.1	GDP-mannose pyrophosphatase	-
HV346_RS10965	2282242..2283021	+	780	WP_181623510.1	DeoR/GlpR family DNA-binding transcription regulator	-
HV346_RS10970	2283114..2284283	+	1170	WP_181623511.1	serine hydrolase	-
HV346_RS10975	2284280..2284816	-	537	WP_181623512.1	aldo/keto reductase	-
HV346_RS10980	2284983..2285834	-	852	WP_181623513.1	aldo/keto reductase	-
HV346_RS10985	2285918..2286187	-	270	WP_181623514.1	zinc-binding dehydrogenase	-
HV346_RS10990	2286354..2286623	+	270	WP_181623515.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HV346_RS10995	2286623..2287930	+	1308	WP_181623516.1	type II toxin-antitoxin system HipA family toxin	Toxin
HV346_RS11000	2288246..2289211	-	966	WP_181623517.1	LysR family transcriptional regulator	-
HV346_RS11005	2289296..2290273	+	978	WP_181623518.1	nitronate monooxygenase	-
HV346_RS11010	2290495..2292072	-	1578	WP_181623752.1	MCP four helix bundle domain-containing protein	-
HV346_RS11015	2292305..2292592	+	288	WP_181623519.1	VF530 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 48589.97 Da
• Isoelectric Point: 7.5573

>T162958 WP_181623516.1 NZ_CP056199:2286623-2287930 [Enterobacter sp. RHBSTW-00994]
MPKLVTWMNNERVGELTKLPNGAHTFKYEKEWLFNRHARPLSLSLPLQVGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
ARSKQPFDLLSEVGRDSVGAVTLLPPDETVSTQEMTWETLSEKKLERVLSAYQSDIPLGMIAEEDNFRISVAGAQEKTAL
LRSDEGWCIPTGITPTTHIIKLPIGEIKQPNATLDLSDSVDNEYFCLSLAKALGFDVPNVEIIKAGAIRALAVERFDRRW
NTTHSMLLRLPQEDMCQTFGLPSSVKYESDGGPGISHIMTFLLGSSEALKDRHNFMKFQVFQWLLGATDGHAKNFSVFIQ
AGGSYKLTPFYDIISAFPVLGGAGMHISDLKLAMSLSASKGRKTAIDKIYPRHFLATAKALKFPEQQMQEIMQTLAEHIP
LALDTVISSLPNDFSTKVVTSIRSNVLRLHARLCK

Nucleotide

• Length: 1308 bp

>T162958 NZ_CP072200:c4987805-4987422 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10362.82 Da
• Isoelectric Point: 4.7405

>AT162958 WP_181623515.1 NZ_CP056199:2286354-2286623 [Enterobacter sp. RHBSTW-00994]
MKPPMIYSPVQLANTMKLIRQKNNWTQSELAKKIGIKQATISNFENSPDNTTLTTFFKILQSLEMKMALYESDEMSTQSE
KDEQQDLDW

Nucleotide

• Length: 270 bp

>AT162958 NZ_CP072200:c4988047-4987805 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA