Detailed information of TA system TA162957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1095753..1096373
• Replicon: chromosome
• Accession: NZ_CP056199
• Organism: Enterobacter sp. RHBSTW-00994

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: -
• Locus tag: HV346_RS05145
• Protein ID: WP_181622491.1
• Coordinates: 1095753..1095971 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: HV346_RS05150
• Protein ID: WP_181622492.1
• Coordinates: 1095999..1096373 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV346_RS05115	1091759..1092019	+	261	WP_181622486.1	type B 50S ribosomal protein L31	-
HV346_RS05120	1092022..1092162	+	141	WP_003859006.1	type B 50S ribosomal protein L36	-
HV346_RS05125	1092159..1092869	-	711	WP_181622487.1	GNAT family N-acetyltransferase	-
HV346_RS05130	1092970..1094430	+	1461	WP_181622488.1	PLP-dependent aminotransferase family protein	-
HV346_RS05135	1094402..1094869	-	468	WP_181622489.1	hypothetical protein	-
HV346_RS05140	1094990..1095541	-	552	WP_181622490.1	maltose O-acetyltransferase	-
HV346_RS05145	1095753..1095971	-	219	WP_181622491.1	hemolysin expression modulator Hha	Toxin
HV346_RS05150	1095999..1096373	-	375	WP_181622492.1	Hha toxicity modulator TomB	Antitoxin
HV346_RS05155	1096889..1100038	-	3150	WP_181622493.1	multidrug efflux RND transporter permease subunit AcrB	-
HV346_RS05160	1100061..1101254	-	1194	WP_181622494.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8597.97 Da
• Isoelectric Point: 8.9008

>T162957 WP_181622491.1 NZ_CP056199:c1095971-1095753 [Enterobacter sp. RHBSTW-00994]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Nucleotide

• Length: 219 bp

>T162957 NZ_CP072200:c3600440-3600338 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14495.31 Da
• Isoelectric Point: 4.8886

>AT162957 WP_181622492.1 NZ_CP056199:c1096373-1095999 [Enterobacter sp. RHBSTW-00994]
MDEYSPKRHDIAQLKFLCETLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Nucleotide

• Length: 375 bp

>AT162957 NZ_CP072200:3600331-3600476 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT