Detailed information of TA system TA162955

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 375310..377008
• Replicon: chromosome
• Accession: NZ_CP056199
• Organism: Enterobacter sp. RHBSTW-00994

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: HV346_RS01765
• Protein ID: WP_181621916.1
• Coordinates: 375310..376239 (-)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: HV346_RS01770
• Protein ID: WP_181621917.1
• Coordinates: 376226..377008 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV346_RS01760	374142..374618	-	477	WP_181621915.1	GNAT family N-acetyltransferase	-
HV346_RS01765	375310..376239	-	930	WP_181621916.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HV346_RS01770	376226..377008	-	783	WP_181621917.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
HV346_RS01775	377294..380392	+	3099	WP_181621918.1	DEAD/DEAH box helicase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	367543..383299	15756

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (12-275)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (96-247)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35097.47 Da
• Isoelectric Point: 5.7730

>T162955 WP_181621916.1 NZ_CP056199:c376239-375310 [Enterobacter sp. RHBSTW-00994]
MDLRDSYARQVRLLMTVLPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSYADRDTDLAAINDALMRITESLNGR
PGITAIRQENKADEKRIIVNTADAQIKIEVSPVWRGLLLPPTEMPVCEQVEMEYGFTTMNIVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLVGHPRPIAELLAPNWDTPRIATLYAQEFSGMTQRETSLESLLSVTTLLPQAL
KSHLTDRDRQFLLSYKQNTPDWSLYRYPEIQHLPAIRWKLRNLAVLNDKNPAKFAAAVSKLEGVLEQYF

Nucleotide

• Length: 930 bp

>T162955 NZ_CP072200:c1457573-1457355 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29178.41 Da
• Isoelectric Point: 8.1223

>AT162955 WP_181621917.1 NZ_CP056199:c377008-376226 [Enterobacter sp. RHBSTW-00994]
MPNYLNWLMQNTLPGQVLLQSWLTRSGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEPGRQQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTADVTSFTAELKIGDRLLAGSVPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQTLLCASHSIKTNRVMLYLAQRNEHPYFRYLDQSGIETGTGKRQIVPGGWLEP
NYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT162955 NZ_CP072200:c1457974-1457600 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG