Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4630260..4630776 Replicon chromosome
Accession NZ_CP056191
Organism Klebsiella pneumoniae strain RHBSTW-00995

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag HV347_RS22575 Protein ID WP_009309309.1
Coordinates 4630260..4630544 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HV347_RS22580 Protein ID WP_002886901.1
Coordinates 4630534..4630776 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV347_RS22550 4625744..4626052 - 309 WP_020079792.1 PTS sugar transporter subunit IIB -
HV347_RS22555 4626137..4626310 + 174 WP_032412860.1 hypothetical protein -
HV347_RS22560 4626313..4627056 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HV347_RS22565 4627413..4629551 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HV347_RS22570 4629792..4630256 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HV347_RS22575 4630260..4630544 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV347_RS22580 4630534..4630776 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV347_RS22585 4630854..4632764 - 1911 WP_049190859.1 BglG family transcription antiterminator -
HV347_RS22590 4632787..4633941 - 1155 WP_023280781.1 lactonase family protein -
HV347_RS22595 4634008..4634748 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T162947 WP_009309309.1 NZ_CP056191:c4630544-4630260 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T162947 NZ_CP072199:c2763109-2762906 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT162947 WP_002886901.1 NZ_CP056191:c4630776-4630534 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT162947 NZ_CP072199:c2763527-2763159 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGATGAGTATTCGCCTAAGCGGCACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References