Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4522687..4523497 Replicon chromosome
Accession NZ_CP056191
Organism Klebsiella pneumoniae strain RHBSTW-00995

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag HV347_RS22080 Protein ID WP_004178461.1
Coordinates 4522687..4523220 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag HV347_RS22085 Protein ID WP_002887278.1
Coordinates 4523231..4523497 (-) Length 89 a.a.

Genomic Context

HV347_RS22075HV347_RS22100HV347_RS22105HV347_RS22080HV347_RS22085HV347_RS22090HV347_RS22095
Location: 4521518..4522639 (1122 bp)
Type: Others
Protein ID: WP_023280822.1
Location: 4525879..4527264 (1386 bp)
Type: Others
Protein ID: WP_032412712.1
Location: 4527282..4527626 (345 bp)
Type: Others
Protein ID: WP_021441118.1
Location: 4522687..4523220 (534 bp)
Type: Toxin
Protein ID: WP_004178461.1
Location: 4523231..4523497 (267 bp)
Type: Antitoxin
Protein ID: WP_002887278.1
Location: 4523600..4525033 (1434 bp)
Type: Others
Protein ID: WP_023280821.1
Location: 4525023..4525706 (684 bp)
Type: Others
Protein ID: WP_002887273.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HV347_RS220754521518..4522639+1122WP_023280822.1cupin domain-containing protein-
HV347_RS220804522687..4523220-534WP_004178461.1GNAT family N-acetyltransferaseToxin
HV347_RS220854523231..4523497-267WP_002887278.1DUF1778 domain-containing proteinAntitoxin
HV347_RS220904523600..4525033-1434WP_023280821.1Cu(+)/Ag(+) sensor histidine kinase-
HV347_RS220954525023..4525706-684WP_002887273.1copper response regulator transcription factor CusR-
HV347_RS221004525879..4527264+1386WP_032412712.1efflux transporter outer membrane subunit-
HV347_RS221054527282..4527626+345WP_021441118.1cation efflux system protein CusF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T162945 WP_004178461.1 NZ_CP056191:c4523220-4522687 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T162945 NZ_CP072199:1072363-1072674 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGCATATCATTTCCAGGGAACCGTTCAATAACGCAACGAAGCAATATCCCAATGAAGCCACTGCTCTCGAGGCCATTTA
TAAAGCATTGCGACGGGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATCTTGTTCTTTGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAATACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT162945 WP_002887278.1 NZ_CP056191:c4523497-4523231 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT162945 NZ_CP072199:1072671-1073093 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGATTACAGATGCCATTAAGGCGGCCGATGCGCTACTGCGCGCCGTGCCCTTGTTGCAGGGCAGCCGCGCTCAGCAAGA
CTACCGGGAAGCGCTTGAATTGGTGGAATACCTGCTGGAAAACGACGAACACCATCCGCTGATTGACATGCTGGCAAAAA
AGATCGCCGAATATGAAGACAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAGTTACCACAGGGGGTAGCC
GCGCTTCGCGTCCTTATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGTAAAAAGTCGTTGGTTAA
CCAAATCCTGAACGGTAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAGCGTTTCAATCTGCCCCCGGCCC
TGTTCCTGCCGGAAGCGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A060VJ83

Antitoxin

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Source
ID
Structure
PDB5ZGN
AlphaFold DBA0A0H3GLZ1

References