Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3916838..3917457 Replicon chromosome
Accession NZ_CP056191
Organism Klebsiella pneumoniae strain RHBSTW-00995

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HV347_RS19160 Protein ID WP_002892050.1
Coordinates 3917239..3917457 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HV347_RS19155 Protein ID WP_002892066.1
Coordinates 3916838..3917212 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV347_RS19145 3912006..3915152 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HV347_RS19150 3915673..3916653 + 981 WP_014386491.1 IS5-like element ISKpn26 family transposase -
HV347_RS19155 3916838..3917212 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HV347_RS19160 3917239..3917457 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HV347_RS19165 3917616..3918182 + 567 WP_002892030.1 maltose O-acetyltransferase -
HV347_RS19170 3918154..3918294 - 141 WP_004147370.1 hypothetical protein -
HV347_RS19175 3918315..3918785 + 471 WP_002892026.1 YlaC family protein -
HV347_RS19180 3918760..3920211 - 1452 WP_021313732.1 PLP-dependent aminotransferase family protein -
HV347_RS19185 3920312..3921010 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HV347_RS19190 3921007..3921147 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HV347_RS19195 3921147..3921410 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3915673..3916653 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T162944 WP_002892050.1 NZ_CP056191:3917239-3917457 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T162944 NZ_CP072199:c992346-992092 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT162944 WP_002892066.1 NZ_CP056191:3916838-3917212 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT162944 NZ_CP072199:c992095-991751 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGCGA
GTTTGTCGGGCTGAATGGCGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCG
CGGTCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCG
CCGGAACGCCATCAGGCGTTAGCCATTGCCGCACAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGA
TCTGGTTATCGAAAAGCATTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References