Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 810945..811602 Replicon chromosome
Accession NZ_CP056191
Organism Klebsiella pneumoniae strain RHBSTW-00995

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HV347_RS04050 Protein ID WP_002916310.1
Coordinates 811192..811602 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HV347_RS04045 Protein ID WP_002916312.1
Coordinates 810945..811211 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV347_RS04020 806101..807534 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
HV347_RS04025 807653..808381 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HV347_RS04030 808431..808742 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HV347_RS04035 808906..809565 + 660 WP_049191317.1 hemolysin III family protein -
HV347_RS04040 809716..810699 - 984 WP_049191568.1 tRNA-modifying protein YgfZ -
HV347_RS04045 810945..811211 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HV347_RS04050 811192..811602 + 411 WP_002916310.1 protein YgfX Toxin
HV347_RS04055 811609..812130 - 522 WP_004144730.1 flavodoxin FldB -
HV347_RS04060 812231..813127 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HV347_RS04065 813150..813863 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV347_RS04070 813869..815602 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T162933 WP_002916310.1 NZ_CP056191:811192-811602 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T162933 NZ_CP072172:c3909464-3909192 [Rhizobium sp. AB2/73]
ATGGCGTGGCGGATTGAATTTCAACGAGCCGCCGAGCGCGAACTAGACAAACTCGGACATGAGGTTTCCCGCCGAATCTT
GAAGTTTCTTTACGACCGTGTTGCCAAGCTGGATGATCCGCGTGCCATCGGAGAGGCGCTGAAGGGCTCGGAACTCGGCG
ATTTCTGGAAATACAGAGTAGGGGATTATCGTATTATCGCGCACATAGAAGATAGAGCCGTGCGGATACTGATCGTTCGA
ATCGGCAACGGACGTGAAGTCTATCGAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT162933 WP_002916312.1 NZ_CP056191:810945-811211 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT162933 NZ_CP072172:c3909672-3909448 [Rhizobium sp. AB2/73]
ATGCTGGCCCTGAGGCTTCCGCCGGAAATTGAAGCAAGGCTCGATGAGCTCGCCAAGCGTACGGGGCGTAGCAAGAGTTT
TTATGCGCGCGAAGCAATTCTCGAGCATCTTGATGATCTTGAGGATATCTATTTGGCGGAAAAGCGTCTCGAAGAGCTTC
GCCGTGGTGAGAGTGACACCGTTTCGCTGGCCGAACTGATGGCGCGTTATGGCGTGGCGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References