Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 40081..40634 | Replicon | plasmid pRHBSTW-01013_3 |
Accession | NZ_CP056187 | ||
Organism | Citrobacter sp. RHBSTW-01013 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | A0A7L6C0D9 |
Locus tag | HV350_RS26285 | Protein ID | WP_050152488.1 |
Coordinates | 40081..40395 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | A0A7L6C0I8 |
Locus tag | HV350_RS26290 | Protein ID | WP_050074640.1 |
Coordinates | 40398..40634 (-) | Length | 79 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV350_RS26245 | 36117..36662 | - | 546 | WP_181630777.1 | DNA distortion polypeptide 1 | - |
HV350_RS26250 | 37001..37258 | - | 258 | WP_050152485.1 | hypothetical protein | - |
HV350_RS26255 | 37273..37422 | - | 150 | WP_172665488.1 | hypothetical protein | - |
HV350_RS26260 | 37499..37843 | - | 345 | WP_080994273.1 | hypothetical protein | - |
HV350_RS26265 | 37939..38157 | - | 219 | WP_181630736.1 | hypothetical protein | - |
HV350_RS26270 | 38150..38413 | - | 264 | WP_181630784.1 | hypothetical protein | - |
HV350_RS26275 | 38426..38968 | - | 543 | WP_181630786.1 | hypothetical protein | - |
HV350_RS26280 | 39010..39525 | - | 516 | WP_128451845.1 | J domain-containing protein | - |
HV350_RS26285 | 40081..40395 | - | 315 | WP_050152488.1 | CcdB family protein | Toxin |
HV350_RS26290 | 40398..40634 | - | 237 | WP_050074640.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
HV350_RS26295 | 41657..42562 | + | 906 | WP_181630738.1 | replication initiation protein | - |
HV350_RS26300 | 42571..43005 | + | 435 | WP_181630740.1 | hypothetical protein | - |
HV350_RS26305 | 43114..43535 | + | 422 | Protein_53 | DNA distortion polypeptide 3 | - |
HV350_RS26310 | 44467..44652 | + | 186 | WP_050074651.1 | hypothetical protein | - |
HV350_RS26315 | 44743..45024 | - | 282 | WP_050074636.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | gnd / galF / manC / manB / gmd | 1..73037 | 73037 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11747.75 Da Isoelectric Point: 6.9730
>T162929 WP_050152488.1 NZ_CP056187:c40395-40081 [Citrobacter sp. RHBSTW-01013]
MQFTVYQNTGKTTIYPYLLDVTSDIIGQLNRRIVIPLLPLEKYPTGKRPERMIPIIMLTDGNEYAVMTHELASIPVRALG
AEFCTAVQYRSQVKASIDFLLDGI
MQFTVYQNTGKTTIYPYLLDVTSDIIGQLNRRIVIPLLPLEKYPTGKRPERMIPIIMLTDGNEYAVMTHELASIPVRALG
AEFCTAVQYRSQVKASIDFLLDGI
Download Length: 315 bp
>T162929 NZ_CP072172:2208309-2208575 [Rhizobium sp. AB2/73]
ATGTTGCTTGCCTGGCACGCACATGCTTGGGAAGACTATTTATATTGGCGGGAAAGAGATCGTAAAATAGCTGTTAGAAT
CAACGAGCTTTTGCGGGACGCACTACGCCACCCGTTTGAGGGACTCGGCAAACCTGAGGCCCTGCGCAATCAACTCAAAG
GACAATGGTCGCGTCGCATCACGCAAGAGCACAGGCTGATTTACAAAGTCGAAGGTGAAGGCGATCGGCAAATACTTATC
GTTTTGCAATGTCGCTTCCACTATTAG
ATGTTGCTTGCCTGGCACGCACATGCTTGGGAAGACTATTTATATTGGCGGGAAAGAGATCGTAAAATAGCTGTTAGAAT
CAACGAGCTTTTGCGGGACGCACTACGCCACCCGTTTGAGGGACTCGGCAAACCTGAGGCCCTGCGCAATCAACTCAAAG
GACAATGGTCGCGTCGCATCACGCAAGAGCACAGGCTGATTTACAAAGTCGAAGGTGAAGGCGATCGGCAAATACTTATC
GTTTTGCAATGTCGCTTCCACTATTAG
Antitoxin
Download Length: 79 a.a. Molecular weight: 8923.99 Da Isoelectric Point: 5.8061
>AT162929 WP_050074640.1 NZ_CP056187:c40634-40398 [Citrobacter sp. RHBSTW-01013]
MATKQRNTQSVTMTLERGLLNQAREAGINLSATLVAALDAELRRYAAQKWQKENMEALDALNRFHDENGCFSDEYRTF
MATKQRNTQSVTMTLERGLLNQAREAGINLSATLVAALDAELRRYAAQKWQKENMEALDALNRFHDENGCFSDEYRTF
Download Length: 237 bp
>AT162929 NZ_CP072172:2208041-2208301 [Rhizobium sp. AB2/73]
ATGCGAACGGTCATGTTTTCAGCAGCACGAAATGAACTTGCTAGCTTGCTTGACGAAGTCGTGCAGGACCGTGTTGCCGT
GGAAATTGTTCGTCGCGATAAGCCGTCAGCCATTCTGATCGACAAGGAAGAATATGAAGGTATCATCGAGACGCTTCATG
TCCTGTCGACCCCGGCCAATGCGGCGCGGTTGATGGAAGCGATTACCGATGCAAACGAGGGAAAGAACCTCGTTTCTCAC
GATTTGATTGATCCGAAGTAA
ATGCGAACGGTCATGTTTTCAGCAGCACGAAATGAACTTGCTAGCTTGCTTGACGAAGTCGTGCAGGACCGTGTTGCCGT
GGAAATTGTTCGTCGCGATAAGCCGTCAGCCATTCTGATCGACAAGGAAGAATATGAAGGTATCATCGAGACGCTTCATG
TCCTGTCGACCCCGGCCAATGCGGCGCGGTTGATGGAAGCGATTACCGATGCAAACGAGGGAAAGAACCTCGTTTCTCAC
GATTTGATTGATCCGAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7L6C0D9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7L6C0I8 |