Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 4451557..4452084 | Replicon | chromosome |
| Accession | NZ_CP056185 | ||
| Organism | Citrobacter sp. RHBSTW-01013 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | HV350_RS21340 | Protein ID | WP_094760972.1 |
| Coordinates | 4451557..4451832 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | HV350_RS21345 | Protein ID | WP_094760973.1 |
| Coordinates | 4451836..4452084 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV350_RS21310 | 4447688..4448050 | + | 363 | WP_016155589.1 | endoribonuclease SymE | - |
| HV350_RS21315 | 4448108..4448593 | - | 486 | WP_003830101.1 | type VI secretion system tube protein Hcp | - |
| HV350_RS21320 | 4448612..4448938 | - | 327 | WP_149382327.1 | DUF1493 family protein | - |
| HV350_RS21325 | 4448932..4449381 | - | 450 | WP_137367027.1 | hypothetical protein | - |
| HV350_RS21330 | 4449640..4450512 | + | 873 | WP_181629283.1 | HNH endonuclease | - |
| HV350_RS21335 | 4450647..4451441 | - | 795 | WP_094760971.1 | helix-turn-helix transcriptional regulator | - |
| HV350_RS21340 | 4451557..4451832 | - | 276 | WP_094760972.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HV350_RS21345 | 4451836..4452084 | - | 249 | WP_094760973.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| HV350_RS21350 | 4452161..4452994 | - | 834 | WP_094760974.1 | DUF4942 domain-containing protein | - |
| HV350_RS21355 | 4453110..4453451 | - | 342 | WP_094760975.1 | TA system toxin CbtA family protein | - |
| HV350_RS21360 | 4453495..4453836 | - | 342 | WP_094760976.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| HV350_RS21365 | 4453859..4454080 | - | 222 | WP_094760977.1 | DUF987 family protein | - |
| HV350_RS21370 | 4454077..4454586 | - | 510 | WP_171862414.1 | DNA repair protein RadC | - |
| HV350_RS21375 | 4454598..4455017 | - | 420 | WP_094760978.1 | antirestriction protein | - |
| HV350_RS21380 | 4455131..4455949 | - | 819 | WP_094760979.1 | DUF945 domain-containing protein | - |
| HV350_RS21385 | 4456066..4456296 | - | 231 | WP_094760980.1 | hypothetical protein | - |
| HV350_RS21390 | 4456293..4456526 | - | 234 | WP_094760981.1 | DUF905 domain-containing protein | - |
| HV350_RS21395 | 4456632..4456907 | - | 276 | WP_094760982.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4448612..4483253 | 34641 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10981.34 Da Isoelectric Point: 4.8888
>T162926 WP_094760972.1 NZ_CP056185:c4451832-4451557 [Citrobacter sp. RHBSTW-01013]
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLDRLITGCAGLAAHPAIGVQQPRYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLDRLITGCAGLAAHPAIGVQQPRYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER
Download Length: 276 bp
>T162926 NZ_CP072172:766987-767283 [Rhizobium sp. AB2/73]
GTGAAACTTGCTTGGACTCCCGAAGCAAGGGCTGACCGACGCGCAATCTATACCTACATCGAGGCCGAGAATGCCACCGC
CGCACTCGCGCTGGACGAACTCTTGGCCAAACGGTCGAAACAGCTCATTACTCATCCAATGACGGGCCGACCCGGCCGCG
TGTCCGGGACACGCGAGCTCGTCGTGCACAGAAACTATCTGCTGGTTTATGATCTTGCTGATGAAATGGTGCGCATAATC
CGCATTCTGCATGCCGCACAGCAATGGCCGCCGAGCGATTTTCAGCCGATTCCCTAG
GTGAAACTTGCTTGGACTCCCGAAGCAAGGGCTGACCGACGCGCAATCTATACCTACATCGAGGCCGAGAATGCCACCGC
CGCACTCGCGCTGGACGAACTCTTGGCCAAACGGTCGAAACAGCTCATTACTCATCCAATGACGGGCCGACCCGGCCGCG
TGTCCGGGACACGCGAGCTCGTCGTGCACAGAAACTATCTGCTGGTTTATGATCTTGCTGATGAAATGGTGCGCATAATC
CGCATTCTGCATGCCGCACAGCAATGGCCGCCGAGCGATTTTCAGCCGATTCCCTAG
Antitoxin
Download Length: 83 a.a. Molecular weight: 8987.33 Da Isoelectric Point: 8.8294
>AT162926 WP_094760973.1 NZ_CP056185:c4452084-4451836 [Citrobacter sp. RHBSTW-01013]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSNMVDFANRLK
KA
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSNMVDFANRLK
KA
Download Length: 249 bp
>AT162926 NZ_CP072172:766700-766990 [Rhizobium sp. AB2/73]
ATGACCGACGCGACATTTACCTTCCGAGTTGAAGAAGAGTTGAAGGCGGCTTTCAGCGAGGCTGCGAAAGCGCATGATCA
AACCGGTGCGCAATTGCTCCGGGCTTTCATGCGCGATTATGTGCGGCGCCAGCAAGATGCCGCCGAATATGACATTTGGT
TTCGCCAGCAGGTTCAGGCCGGTCTTACTTCCGCCAATGCCGGCAACCTCATTCCCGACGACGACGTGGACGCTGAATTT
GCCGCCTTGCGAGAAGAAACACGCCGCAAACTCAGCGGGCGTTCTTCGTGA
ATGACCGACGCGACATTTACCTTCCGAGTTGAAGAAGAGTTGAAGGCGGCTTTCAGCGAGGCTGCGAAAGCGCATGATCA
AACCGGTGCGCAATTGCTCCGGGCTTTCATGCGCGATTATGTGCGGCGCCAGCAAGATGCCGCCGAATATGACATTTGGT
TTCGCCAGCAGGTTCAGGCCGGTCTTACTTCCGCCAATGCCGGCAACCTCATTCCCGACGACGACGTGGACGCTGAATTT
GCCGCCTTGCGAGAAGAAACACGCCGCAAACTCAGCGGGCGTTCTTCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|