Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4451557..4452084 Replicon chromosome
Accession NZ_CP056185
Organism Citrobacter sp. RHBSTW-01013

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HV350_RS21340 Protein ID WP_094760972.1
Coordinates 4451557..4451832 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HV350_RS21345 Protein ID WP_094760973.1
Coordinates 4451836..4452084 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV350_RS21310 4447688..4448050 + 363 WP_016155589.1 endoribonuclease SymE -
HV350_RS21315 4448108..4448593 - 486 WP_003830101.1 type VI secretion system tube protein Hcp -
HV350_RS21320 4448612..4448938 - 327 WP_149382327.1 DUF1493 family protein -
HV350_RS21325 4448932..4449381 - 450 WP_137367027.1 hypothetical protein -
HV350_RS21330 4449640..4450512 + 873 WP_181629283.1 HNH endonuclease -
HV350_RS21335 4450647..4451441 - 795 WP_094760971.1 helix-turn-helix transcriptional regulator -
HV350_RS21340 4451557..4451832 - 276 WP_094760972.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV350_RS21345 4451836..4452084 - 249 WP_094760973.1 ribbon-helix-helix domain-containing protein Antitoxin
HV350_RS21350 4452161..4452994 - 834 WP_094760974.1 DUF4942 domain-containing protein -
HV350_RS21355 4453110..4453451 - 342 WP_094760975.1 TA system toxin CbtA family protein -
HV350_RS21360 4453495..4453836 - 342 WP_094760976.1 type IV toxin-antitoxin system YeeU family antitoxin -
HV350_RS21365 4453859..4454080 - 222 WP_094760977.1 DUF987 family protein -
HV350_RS21370 4454077..4454586 - 510 WP_171862414.1 DNA repair protein RadC -
HV350_RS21375 4454598..4455017 - 420 WP_094760978.1 antirestriction protein -
HV350_RS21380 4455131..4455949 - 819 WP_094760979.1 DUF945 domain-containing protein -
HV350_RS21385 4456066..4456296 - 231 WP_094760980.1 hypothetical protein -
HV350_RS21390 4456293..4456526 - 234 WP_094760981.1 DUF905 domain-containing protein -
HV350_RS21395 4456632..4456907 - 276 WP_094760982.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4448612..4483253 34641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10981.34 Da        Isoelectric Point: 4.8888

>T162926 WP_094760972.1 NZ_CP056185:c4451832-4451557 [Citrobacter sp. RHBSTW-01013]
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLDRLITGCAGLAAHPAIGVQQPRYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER

Download         Length: 276 bp

>T162926 NZ_CP072172:766987-767283 [Rhizobium sp. AB2/73]
GTGAAACTTGCTTGGACTCCCGAAGCAAGGGCTGACCGACGCGCAATCTATACCTACATCGAGGCCGAGAATGCCACCGC
CGCACTCGCGCTGGACGAACTCTTGGCCAAACGGTCGAAACAGCTCATTACTCATCCAATGACGGGCCGACCCGGCCGCG
TGTCCGGGACACGCGAGCTCGTCGTGCACAGAAACTATCTGCTGGTTTATGATCTTGCTGATGAAATGGTGCGCATAATC
CGCATTCTGCATGCCGCACAGCAATGGCCGCCGAGCGATTTTCAGCCGATTCCCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8987.33 Da        Isoelectric Point: 8.8294

>AT162926 WP_094760973.1 NZ_CP056185:c4452084-4451836 [Citrobacter sp. RHBSTW-01013]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSNMVDFANRLK
KA

Download         Length: 249 bp

>AT162926 NZ_CP072172:766700-766990 [Rhizobium sp. AB2/73]
ATGACCGACGCGACATTTACCTTCCGAGTTGAAGAAGAGTTGAAGGCGGCTTTCAGCGAGGCTGCGAAAGCGCATGATCA
AACCGGTGCGCAATTGCTCCGGGCTTTCATGCGCGATTATGTGCGGCGCCAGCAAGATGCCGCCGAATATGACATTTGGT
TTCGCCAGCAGGTTCAGGCCGGTCTTACTTCCGCCAATGCCGGCAACCTCATTCCCGACGACGACGTGGACGCTGAATTT
GCCGCCTTGCGAGAAGAAACACGCCGCAAACTCAGCGGGCGTTCTTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References