Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3749685..3750305 | Replicon | chromosome |
Accession | NZ_CP056185 | ||
Organism | Citrobacter sp. RHBSTW-01013 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | HV350_RS18085 | Protein ID | WP_002892050.1 |
Coordinates | 3750087..3750305 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | A0A7L6U5G9 |
Locus tag | HV350_RS18080 | Protein ID | WP_019076175.1 |
Coordinates | 3749685..3750059 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV350_RS18070 | 3744832..3746025 | + | 1194 | WP_016152074.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
HV350_RS18075 | 3746048..3749197 | + | 3150 | WP_016152073.1 | multidrug efflux RND transporter permease subunit | - |
HV350_RS18080 | 3749685..3750059 | + | 375 | WP_019076175.1 | Hha toxicity modulator TomB | Antitoxin |
HV350_RS18085 | 3750087..3750305 | + | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
HV350_RS18090 | 3750486..3751037 | + | 552 | WP_181629072.1 | maltose O-acetyltransferase | - |
HV350_RS18095 | 3751154..3751624 | + | 471 | WP_016152071.1 | YlaC family protein | - |
HV350_RS18100 | 3751703..3751843 | - | 141 | WP_005125190.1 | type B 50S ribosomal protein L36 | - |
HV350_RS18105 | 3751845..3752105 | - | 261 | WP_016152070.1 | type B 50S ribosomal protein L31 | - |
HV350_RS18110 | 3752294..3753846 | + | 1553 | Protein_3552 | EAL domain-containing protein | - |
HV350_RS18115 | 3753898..3754251 | - | 354 | WP_003831033.1 | DUF1428 family protein | - |
HV350_RS18120 | 3754316..3754945 | - | 630 | WP_016155872.1 | membrane protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T162924 WP_002892050.1 NZ_CP056185:3750087-3750305 [Citrobacter sp. RHBSTW-01013]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T162924 NZ_CP072172:74199-74468 [Rhizobium sp. AB2/73]
GTGGCATGGACGATTGAGTATGCGCGATCTGCTCGCAAATTTGTCGAAAAACTGAATCCGGAGACACGTAAGAGAATAAG
GAGTTTTCTCGAGGAACGTCTCGCCACTTTGCATGATCCCCGTCAGGTTGGCGATGCTCTGCAGGGTGCGCGGTTGGGGA
ATTACTGGCGTTATCGAGTCGGCGATTACCGAATTATCTGCGACCTGCAGGATAGTCGCCTGGTTGTGCTTGTTATCGAA
ATCGGAAACCGTCGCGACGTCTATCGTTAG
GTGGCATGGACGATTGAGTATGCGCGATCTGCTCGCAAATTTGTCGAAAAACTGAATCCGGAGACACGTAAGAGAATAAG
GAGTTTTCTCGAGGAACGTCTCGCCACTTTGCATGATCCCCGTCAGGTTGGCGATGCTCTGCAGGGTGCGCGGTTGGGGA
ATTACTGGCGTTATCGAGTCGGCGATTACCGAATTATCTGCGACCTGCAGGATAGTCGCCTGGTTGTGCTTGTTATCGAA
ATCGGAAACCGTCGCGACGTCTATCGTTAG
Antitoxin
Download Length: 125 a.a. Molecular weight: 14413.20 Da Isoelectric Point: 5.5653
>AT162924 WP_019076175.1 NZ_CP056185:3749685-3750059 [Citrobacter sp. RHBSTW-01013]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT162924 NZ_CP072172:73988-74215 [Rhizobium sp. AB2/73]
ATGAGCAAACAAACCGCCATCCGTCTGCCAGATGAAACCTACGAGCGCCTGCAGGCTCTGGCCACGCGAACGGGCCGGAC
CGCAACCTTCTACATTCGTCAAGCCGTTGAGGCTCACTTGGACGAAATGGAAGACGTATACTTAGCAGAACGCGCCATGG
AGCGAATTAAGAACGGTGAAGACGAGGTCGTAAGCTCCGAGGAATTCTGGCGTGGCATGGACGATTGA
ATGAGCAAACAAACCGCCATCCGTCTGCCAGATGAAACCTACGAGCGCCTGCAGGCTCTGGCCACGCGAACGGGCCGGAC
CGCAACCTTCTACATTCGTCAAGCCGTTGAGGCTCACTTGGACGAAATGGAAGACGTATACTTAGCAGAACGCGCCATGG
AGCGAATTAAGAACGGTGAAGACGAGGTCGTAAGCTCCGAGGAATTCTGGCGTGGCATGGACGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7L6U5G9 |