Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
Location | 3087955..3088545 | Replicon | chromosome |
Accession | NZ_CP056185 | ||
Organism | Citrobacter sp. RHBSTW-01013 |
Toxin (Protein)
Gene name | pemK | Uniprot ID | A0A7L6BU22 |
Locus tag | HV350_RS14950 | Protein ID | WP_049282111.1 |
Coordinates | 3087955..3088287 (-) | Length | 111 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | A0A7L6BU61 |
Locus tag | HV350_RS14955 | Protein ID | WP_049282110.1 |
Coordinates | 3088288..3088545 (-) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV350_RS14925 | 3082991..3083350 | - | 360 | WP_016156204.1 | purine nucleoside phosphoramidase | - |
HV350_RS14930 | 3083699..3085885 | + | 2187 | WP_181628813.1 | ferric-rhodotorulic acid/ferric-coprogen receptor FhuE | - |
HV350_RS14940 | 3086064..3087707 | + | 1644 | WP_181628814.1 | EmmdR/YeeO family multidrug/toxin efflux MATE transporter | - |
HV350_RS14950 | 3087955..3088287 | - | 333 | WP_049282111.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
HV350_RS14955 | 3088288..3088545 | - | 258 | WP_049282110.1 | antitoxin | Antitoxin |
HV350_RS14960 | 3089157..3093056 | + | 3900 | Protein_2940 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11758.56 Da Isoelectric Point: 8.5572
>T162923 WP_049282111.1 NZ_CP056185:c3088287-3087955 [Citrobacter sp. RHBSTW-01013]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGNFARAAGFTVSLDGVGTKTTGVIRCDQPRTI
DMGARNGKCLERIPEAVVNEVLARLEAILN
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGNFARAAGFTVSLDGVGTKTTGVIRCDQPRTI
DMGARNGKCLERIPEAVVNEVLARLEAILN
Download Length: 333 bp
>T162923 NZ_CP072168:c283468-283175 [Agrobacterium larrymoorei]
TTGAGACTAACGTGGTCCGCGTTTGCCTTATCGGATCGCGACACAATTTTTACTTTCATCGAGTTGGAGAACGCGGCCGC
TGCCATTTTGGTCGACGAACGTATCGTCGTTGCAGTCCGTCGCCTGATCGATTTTCCAGCAAGTGGCAGGGCCGGAAGAA
TTGCTGGGACACGTGAACTTGTAATCAGCGGAACGCCTTACGTCGCAGTATATACGATCACAGAAGCTACGGTTCGAGTA
CTGCGTATTTTGCACGGGGCTCAGGAATGGCCTGAAGCTTTTTCAATCAGTTAG
TTGAGACTAACGTGGTCCGCGTTTGCCTTATCGGATCGCGACACAATTTTTACTTTCATCGAGTTGGAGAACGCGGCCGC
TGCCATTTTGGTCGACGAACGTATCGTCGTTGCAGTCCGTCGCCTGATCGATTTTCCAGCAAGTGGCAGGGCCGGAAGAA
TTGCTGGGACACGTGAACTTGTAATCAGCGGAACGCCTTACGTCGCAGTATATACGATCACAGAAGCTACGGTTCGAGTA
CTGCGTATTTTGCACGGGGCTCAGGAATGGCCTGAAGCTTTTTCAATCAGTTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9398.91 Da Isoelectric Point: 4.4620
>AT162923 WP_049282110.1 NZ_CP056185:c3088545-3088288 [Citrobacter sp. RHBSTW-01013]
MYTTRLKKVGGSIMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEEREWIDAPAV
GKEIL
MYTTRLKKVGGSIMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEEREWIDAPAV
GKEIL
Download Length: 258 bp
>AT162923 NZ_CP072168:c283773-283465 [Agrobacterium larrymoorei]
ATGGCTGCAAATGCGCTCGTTCAAACTCGTATCGATGCTGACGTTCGTGACCGGGCGTCCCTCGTTCTGGAAGGTATGGG
ACTTACGGTGTCAGACGCGGTTCGCATATTGCTTACGAGGACCGCCAATGAGGGCATGTTGCCGCTTGAACTTCTTTCAG
GCAGCGAGGCTCACGATACCTGGTTTCGTGCAAAGGTGCTTGAGGCGCTAAATGACACAAGACCGGATATTTCCGACGAT
GAAGTGGAAGCCCATTTCGAAAAGCGTCGGCATTCTGCGCGCAATAACGCGGCGGGTATAACGTCTTGA
ATGGCTGCAAATGCGCTCGTTCAAACTCGTATCGATGCTGACGTTCGTGACCGGGCGTCCCTCGTTCTGGAAGGTATGGG
ACTTACGGTGTCAGACGCGGTTCGCATATTGCTTACGAGGACCGCCAATGAGGGCATGTTGCCGCTTGAACTTCTTTCAG
GCAGCGAGGCTCACGATACCTGGTTTCGTGCAAAGGTGCTTGAGGCGCTAAATGACACAAGACCGGATATTTCCGACGAT
GAAGTGGAAGCCCATTTCGAAAAGCGTCGGCATTCTGCGCGCAATAACGCGGCGGGTATAACGTCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7L6BU22 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7L6BU61 |