Detailed information of TA system TA162905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 4336785..4337304
• Replicon: chromosome
• Accession: NZ_CP056180
• Organism: Citrobacter sp. RHBSTW-01044

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8I0G602
• Locus tag: HV352_RS20760
• Protein ID: WP_047414720.1
• Coordinates: 4336785..4337066 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0V9JX71
• Locus tag: HV352_RS20765
• Protein ID: WP_016155558.1
• Coordinates: 4337056..4337304 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV352_RS20745	4333787..4334251	+	465	WP_016151476.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HV352_RS20750	4334273..4334794	-	522	WP_019078246.1	hypothetical protein	-
HV352_RS20755	4334794..4336758	-	1965	WP_181635061.1	type VI secretion system tip protein VgrG	-
HV352_RS20760	4336785..4337066	-	282	WP_047414720.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV352_RS20765	4337056..4337304	-	249	WP_016155558.1	hypothetical protein	Antitoxin
HV352_RS20770	4337599..4338072	-	474	WP_016155556.1	hypothetical protein	-
HV352_RS20775	4338115..4340616	-	2502	WP_181635062.1	type VI secretion system ATPase TssH	-
HV352_RS20780	4340607..4341554	-	948	WP_181635063.1	type VI secretion system baseplate subunit TssG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10974.73 Da
• Isoelectric Point: 10.4466

>T162905 WP_047414720.1 NZ_CP056180:c4337066-4336785 [Citrobacter sp. RHBSTW-01044]
MTYNLEFLDVALKEWRKLSPALREQFKKKLAERLENPHVPAARLSGKLHRYKIKLRSAGYRLVYQVEDEQVVVLVIAVGR
RDGDEVYHQANRR

Nucleotide

• Length: 282 bp

>T162905 NZ_CP072162:3253401-3253661 [Rhizobium sp. B21/90]
ATGAAAATTACGTGGGACGAGCGCAAGCGGCTCGCAAATTTCGACAAGCACGGCCTCGATTTCGCCGAACTCGACGCGGA
TTTCTTTCTTGCAGCTCTTTTGCAACCGGCAAAACTCGGACGGTTCAAGGCCATCGGGCGACGACATGACGGTACGACCG
CAGTCATCTTCGCCGTTCTCGGGCGCGAGGCGGTCTCGGTAATATCGATGCGGCCTGCGCACAAAGCCGAAAGGAGCCTG
TTGAATGACAAAGAAAACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8987.28 Da
• Isoelectric Point: 4.7513

>AT162905 WP_016155558.1 NZ_CP056180:c4337304-4337056 [Citrobacter sp. RHBSTW-01044]
MPFHILTKTAASITDLKRNPMGTVNAGEGEAVAILNRNEPAFYCVPPAVYAYLLELAEDAELNRIADEREGGKRIKVSLN
DL

Nucleotide

• Length: 249 bp

>AT162905 NZ_CP072162:3253645-3253953 [Rhizobium sp. B21/90]
ATGACAAAGAAAACTGAAATGCGGAGCGACTTCCAGAATGGCCGGGGCTATTCAGACCAGGATTGGGAGGAGGTTTCCGA
CAATCCTGAATGGACCGAGGAAGACTTCAAGAATGCCCGTCCGTTTGCCGAGGTTTTCCCGGATCTGGCGGAAAGCATTC
GCCGGGCCCGGGGGCGACCGGCGGTCGAGGCGCCGAAGCGGCAAATCTCGCTGCGGCTCGATCCCGATGTCATCGATGCC
TTCAAGGCCACCGGCAAGGGCTGGCAGAGCCGTATCAACGAGGCTTTGCGCAAGGCGGCCAAAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0V9JX71