162903

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3655068..3655688 Replicon chromosome
Accession NZ_CP056180
Organism Citrobacter sp. RHBSTW-01044

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HV352_RS17745 Protein ID WP_002892050.1
Coordinates 3655470..3655688 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag HV352_RS17740 Protein ID WP_019076175.1
Coordinates 3655068..3655442 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV352_RS17730 3650215..3651408 + 1194 WP_053389373.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV352_RS17735 3651431..3654580 + 3150 WP_016152073.1 multidrug efflux RND transporter permease subunit -
HV352_RS17740 3655068..3655442 + 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
HV352_RS17745 3655470..3655688 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HV352_RS17750 3655869..3656420 + 552 WP_016155874.1 maltose O-acetyltransferase -
HV352_RS17755 3656537..3657007 + 471 WP_016152071.1 YlaC family protein -
HV352_RS17760 3657086..3657226 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
HV352_RS17765 3657228..3657488 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
HV352_RS17770 3657677..3659230 + 1554 WP_016155873.1 EAL domain-containing protein -
HV352_RS17775 3659282..3659635 - 354 WP_003831033.1 DUF1428 family protein -
HV352_RS17780 3659700..3660329 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T162903 WP_002892050.1 NZ_CP056180:3655470-3655688 [Citrobacter sp. RHBSTW-01044]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T162903 NZ_CP072162:c3083261-3082989 [Rhizobium sp. B21/90]
ATGGCGTGGAGGATTGAGTTTCAGCGGCCGGCGGAACGCGATCTTGAAAAGCTCGATCATGAGAGCGTGAAAAGGATACT
CCGTTTCCTTCACACGCGTGTCGCCAGCCTCGAGGACCCCCGGTCGATAGGGGAGGCGCTTCGCGGATCGGAACTTGGAA
ACTTCTGGAAGTATCGTGTTGGAGACTATCGCATCATTGCCGACATAGACGACGGCACCGTTCGGATATTGGTCGTCCGC
ATTGGCAATCGGAAGGACGTCTATCGCCGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT162903 WP_019076175.1 NZ_CP056180:3655068-3655442 [Citrobacter sp. RHBSTW-01044]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT162903 NZ_CP072162:c3083469-3083245 [Rhizobium sp. B21/90]
ATGCTTGCCCTGCGTTTGCCTCCTGACATTGAAGCAAGACTAGATGAGCTCGCCAAACGCACCGGGCGGAGCAAGAGCTT
CTATGCGCGTCAAGCGATATTGGAACACTTGGACGATCTGGAAGACCTCTACGTCGCCGAGCAGAGGCTCGAAGAATTCC
GTAGAGGCGACAGTGATAGCATTTCTCTCGCTGAGTTGATGGCGCGCCATGGCGTGGAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References