Detailed information of TA system TA162893

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2320710..2321346
• Replicon: chromosome
• Accession: NZ_CP056180
• Organism: Citrobacter sp. RHBSTW-01044

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2I8S6E9
• Locus tag: HV352_RS11215
• Protein ID: WP_049259794.1
• Coordinates: 2320710..2320898 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HV352_RS11220
• Protein ID: WP_131382557.1
• Coordinates: 2320930..2321346 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV352_RS11195	2317488..2317718	-	231	WP_019076831.1	DUF2554 family protein	-
HV352_RS11200	2317908..2318033	-	126	WP_104651600.1	DUF2474 domain-containing protein	-
HV352_RS11205	2318033..2319043	-	1011	WP_016153157.1	cytochrome d ubiquinol oxidase subunit II	-
HV352_RS11210	2319043..2320446	-	1404	WP_016153156.1	cytochrome ubiquinol oxidase subunit I	-
HV352_RS11215	2320710..2320898	+	189	WP_049259794.1	type II toxin-antitoxin system HicA family toxin	Toxin
HV352_RS11220	2320930..2321346	+	417	WP_131382557.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HV352_RS11225	2321439..2322848	+	1410	WP_181635429.1	PLP-dependent aminotransferase family protein	-
HV352_RS11230	2323178..2324323	+	1146	WP_016153154.1	ABC transporter substrate-binding protein	-
HV352_RS11235	2324340..2325356	+	1017	WP_016156582.1	ABC transporter ATP-binding protein	-
HV352_RS11240	2325357..2326301	+	945	WP_016153152.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-64)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7102.16 Da
• Isoelectric Point: 11.5775

>T162893 WP_049259794.1 NZ_CP056180:2320710-2320898 [Citrobacter sp. RHBSTW-01044]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Nucleotide

• Length: 189 bp

>T162893 NZ_CP072157:3788-4666 [Rhizobium sp. B230/85]
ATGGCTAAAGCACCAGCGAACATGGCGAAGTCGGTCAAGGATCGGCTGCTCAATATCGCCCGCAAAGAAAGTCGCGCCTT
CGACGTCTTGCTGGTGCGGTTCGCGCTCGAACGGCTGCTGTATCGCCTGTCAATCTCAGCGCATCGGGACCGCTTCGTCC
TGAAAGGCGGTATGTTGGTAACGGTCTGGGTGGCCGACGATAATCGGGTGACGCGGGATGCGGACTTTCTCGGACATGGA
GACGCAGATCCTGCCCGCCTGATCACCGACTTCGGTGAGATCATGGCGATTGAGAGCGACGACGGACTCGCCTTCGACAT
CGATGCGCTCGCTGCAACAGTCATACGAGAAGAAATGGAATATGGTGGCGTTCGTCTCAAGACCGCCGCCTATCTCGAAA
GGACCCGCATCCCCGTTACAATCGACATCGGCTTCGGAGACGCTATGGCCGATGCGACGCAGCGGCTCGACTATCCAGCC
CTGCTGGATTTTCCCGCTCCGCAGGTTCGTTCCTATCCGCCCGCCACGGTGATCGCCGAGAAATTCCAGGCGATGGTGGC
GCTTGGCGTCCTCAACGGGCGCATGAAGGACTATTACGACCTGTGGGCGATACCGCGCGCGATCGACATTCCCGCTGCCG
ATCTGGATGCGGCCATCCGCGCGACGTTTGAACGCCGCCGGACGCCAATCCCTAAAGAACGCCCACCAGGCCTCTCTGTC
ACAATGTTTGGCGACGAAGGAAAGCAAAGGCAATGGCGTGCTTACGCCGCAACGCTTGAACTCGACGCTGTTTCGCTGGA
ATCGATCATTGAACGGGTTTGGGAGTTGGTCGGCCCGTCATGCGCGCGGATCATAGCAAGAAACGAGAATGAGGCATGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15064.33 Da
• Isoelectric Point: 4.7119

>AT162893 WP_131382557.1 NZ_CP056180:2320930-2321346 [Citrobacter sp. RHBSTW-01044]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGTEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Nucleotide

• Length: 417 bp

>AT162893 NZ_CP072157:3175-3795 [Rhizobium sp. B230/85]
ATGCCATCGGCGCAAGATTCGCAAAAAGTGAAGCTCAGAAGCCTGCTCAATGCGCGCAGCATGATGCATGCGTATGAGCT
GCGCGAGGCTGGCATAAGCGCGCAAACGATTGCGCGCGCCGTCGAGGGCGGTGAAATCGAGCGTATCTCGCGCGGAGTTT
ATCAGAAGCGTGACGCGGAAATCGAAGAGAACCAGATCCTTGCTGAAGCCATCATGCGTGCGCCCAAAGGCGTCATCGCT
CTGGTCTCGGCGCTCGCCTTCCACGAACTGACCGACCAGATGCCGCGGCGCGTTTGGATAGCGATCGGGACGACCGATTG
GGCGCCCGTACAGTCCTATCCCCCGCTGCGTATGGTCCGCTTCACGGAACCCTATCTGCGACAGGGCATCGAACATCAAG
TAATCGCCGGCATTGACGTTCCGGTCTATTCGATCCCGAAAACCCTTGCTGACCTGTTCCGAAACCCCAAACTGGTGGAC
CGATCGGTTGCTGTCGAAGGACTGCGTGCTGCTCTAAAGCAACGCAAGGCAACTCCAAGCGCAATCGCCCAGGCCGCGAA
GGCCGGCGGCGCCTGGAAGGTCATGCAACCCTATCTTGAGGCGCTCACCTCCAATGGCTAA

Structures

Toxin

• AlphaFold DB: A0A2I8S6E9