Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 261525..262121 Replicon chromosome
Accession NZ_CP056168
Organism Enterobacter roggenkampii strain RHBSTW-00695

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F1DED9
Locus tag HV268_RS01170 Protein ID WP_023293553.1
Coordinates 261819..262121 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W7P674
Locus tag HV268_RS01165 Protein ID WP_021242718.1
Coordinates 261525..261812 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV268_RS01160 259896..261528 + 1633 Protein_222 Na/Pi cotransporter family protein -
HV268_RS01165 261525..261812 - 288 WP_021242718.1 putative addiction module antidote protein Antitoxin
HV268_RS01170 261819..262121 - 303 WP_023293553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV268_RS01175 262319..263191 + 873 WP_008503414.1 23S rRNA pseudouridine(2604) synthase RluF -
HV268_RS01180 263192..263464 - 273 WP_014830263.1 DUF3811 domain-containing protein -
HV268_RS01185 263515..264459 - 945 WP_023293551.1 ketopantoate/pantoate/pantothenate transporter PanS -
HV268_RS01190 264565..266139 - 1575 WP_039024657.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11459.24 Da        Isoelectric Point: 10.1771

>T162874 WP_023293553.1 NZ_CP056168:c262121-261819 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T162874 NZ_CP072151:518062-518355 [Rhizobium sp. K15/93]
ATGCCCGAAGTTCGGCAGACGATCTTGTTCAGGCGTTGGTTCGATGGCCTGAAAGACAAGCGTGCGGTTGAGCGGATCAC
CCAGCGTATCGTTCGACTGCAAGCCGGTTTGTTTGGAGACATAAAATTCTTCGATGGCATCGGCGAGTTGCGCGTCGATC
ATGGGCCTGGGTATCGGGTTTATTTTGTGCAGCGCGGATCTGTCCTGGTCATTTTACTGTGGGGCGGCGACAAGAGTTCT
CAAACCCGCGATATACGGAAAGCCAAGGCCATGGCGAATGATTTGGAGATTTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10156.57 Da        Isoelectric Point: 6.4596

>AT162874 WP_021242718.1 NZ_CP056168:c261812-261525 [Enterobacter roggenkampii]
MHKLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp

>AT162874 NZ_CP072151:518356-518658 [Rhizobium sp. K15/93]
TTGCCAGTGAAGACGCTACCTTTCGATGCTGCAGATCATTTGCAGAGCGGCCAATCCCAGCTTGAGTTGCTGAGCGATGC
TTTTAATTCCGGGAGCGCATCCTATGTCGCGGTGGCGTTGGGCGTCATTGCGCGCGCCAAAGGCATGACGGAAGTATCGA
AAACGGCAGGCATCACCCGCGAAGCGCTATACAAAGCTCTCAGCGCCGACGGCGATCCGAAGCTGAGCACGCTGCTTGGC
GTGCTCAACGCTCTCGACCTCCAGCTGAAATTGGCCCCTGGCAACAAAAAAGCCCCGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1DED9

Antitoxin

Source ID Structure
AlphaFold DB W7P674

References