Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 40680..41324 Replicon plasmid pRHBSTW-00777_3
Accession NZ_CP056167
Organism Escherichia marmotae strain RHBSTW-00777

Toxin (Protein)


Gene name hicA Uniprot ID A0A7L6LII1
Locus tag HV276_RS23735 Protein ID WP_000833471.1
Coordinates 41142..41324 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7L6LHN8
Locus tag HV276_RS23730 Protein ID WP_000466317.1
Coordinates 40680..41117 (-) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV276_RS23710 38066..38401 - 336 WP_000963832.1 hypothetical protein -
HV276_RS23715 38770..39171 + 402 WP_181503405.1 zinc transporter -
HV276_RS23720 39189..39950 + 762 WP_075319719.1 conjugal transfer protein TraL -
HV276_RS23725 39947..40651 + 705 WP_080171974.1 hypothetical protein -
HV276_RS23730 40680..41117 - 438 WP_000466317.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HV276_RS23735 41142..41324 - 183 WP_000833471.1 type II toxin-antitoxin system HicA family toxin Toxin
HV276_RS23740 41758..42036 - 279 WP_000545934.1 hypothetical protein -
HV276_RS23745 42094..42423 - 330 WP_000387851.1 hypothetical protein -
HV276_RS23750 42863..43105 - 243 WP_001704452.1 transcriptional regulator -
HV276_RS23755 43095..43361 - 267 WP_000868277.1 hypothetical protein -
HV276_RS23760 43412..43636 - 225 WP_000749828.1 hypothetical protein -
HV276_RS23765 43732..43956 - 225 WP_053528582.1 hypothetical protein -
HV276_RS23770 43997..44320 - 324 WP_080193904.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..46003 46003


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-138)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6675.97 Da        Isoelectric Point: 11.0013

>T162873 WP_000833471.1 NZ_CP056167:c41324-41142 [Escherichia marmotae]
MKSADLLKELIAAGCELKRHKASSHQIWWSPITGKTFPVPHPKKDLPLGTVRSIRKMAGI

Download         Length: 183 bp

>T162873 NZ_CP072151:423190-423453 [Rhizobium sp. K15/93]
ATGGCTTTTGAGTTTGATCCCGACAAAAGCAGAACAAACAAAATCAAGCACGGTATTGATCTTGTGGAGGCGCAGCGTCT
TTGGATCGATCGCTTTTTGATTTCATTCCCCGCTCGGGGCGGACTTGAAAGCCGGTTTGTCGCGGTCGGTCAAATAGACG
GGAAGCATTGGTCCGCGATTTGCACGAGACGTCATGACAATATCAGGATCATTTCGGTTCGCAGGTCGAGGAAAGAGGAG
ATAGCTCTCTATGAAGGCAAGTGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16227.10 Da        Isoelectric Point: 4.3135

>AT162873 WP_000466317.1 NZ_CP056167:c41117-40680 [Escherichia marmotae]
MFFSVGVETPKDDHTAYGITVPAFDRFDFGCVSAADTQSEIPVMAREAILAIVEEMVLSGSYSVDDIHDDGCLTYAANQD
YSHCDSWFVIDVDLSEIEGKQQRINIALPDVLIRRIDGFVRESGGVYRDRSHFLAQAARHELSYK

Download         Length: 438 bp

>AT162873 NZ_CP072151:423440-423667 [Rhizobium sp. K15/93]
ATGAAGGCAAGTGAACTCGACGAGAAATTCGACAATGGCGAGGATATACTCGACTATCTCGACCTCACCAAGGCAACCCG
CCCAAACATGGCGACCCAAAAGGTCAGCGTGGATTTTGCAACCTCAGTGGTCAATAGCCTCGACGAGGAAGCAGCCCGAC
TCGGGCTGACACGGCAATCACTGATCAATTTGTGGATCGAAGAGCGTCTGTCCGCCGCTCAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LII1

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6LHN8

References