Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 73709..74334 Replicon plasmid pRHBSTW-00777_2
Accession NZ_CP056166
Organism Escherichia marmotae strain RHBSTW-00777

Toxin (Protein)


Gene name vapC Uniprot ID A0A7L6LHR5
Locus tag HV276_RS23450 Protein ID WP_000911307.1
Coordinates 73709..74107 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D6IDB0
Locus tag HV276_RS23455 Protein ID WP_000450523.1
Coordinates 74107..74334 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV276_RS23435 69122..71974 + 2853 WP_181503370.1 conjugal transfer mating pair stabilization protein TraG -
HV276_RS23440 71988..72638 + 651 WP_181479340.1 hypothetical protein -
HV276_RS23445 72710..73447 + 738 WP_000927748.1 complement resistance protein TraT -
HV276_RS23450 73709..74107 - 399 WP_000911307.1 tRNA(fMet)-specific endonuclease VapC Toxin
HV276_RS23455 74107..74334 - 228 WP_000450523.1 toxin-antitoxin system antitoxin VapB Antitoxin
HV276_RS23460 74467..76653 + 2187 WP_181503371.1 type IV conjugative transfer system coupling protein TraD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..87925 87925


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14974.31 Da        Isoelectric Point: 8.1432

>T162868 WP_000911307.1 NZ_CP056166:c74107-73709 [Escherichia marmotae]
MLKFMLDTNICIFTIKNKPAHIRERFNLNSGRMCISSVTVMELVYGAEKSQFPERNLAIIEGFISRLDVLDYDCAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERISGLRLEDWC

Download         Length: 399 bp

>T162868 NZ_CP072146:3783085-3783369 [Rhizobium sp. K1/93]
ATGGTAATTCTTTCGTTCAAGGATGGGTCGACGCGCGCCGTTGCTTCCGGCGTTGTGCCGAAAGGCTTTCCCGCCGACCT
TGCGCGACGTGCTATTCGCAAGCTGACCATGATCGAATATGCCAACCAGCTTTCGGACCTACGTTCGCCGCCCGCAAATC
ATCTCGAGGCGTTGAAGGGAGATCGTGCCGGCCAGCATTCCATCCGCATCAACGATCAATGGCGGATTTGCTTCGTCTGG
ACCGATGCTGGCGTCGAAGATGTCGAAATTGTCGATTACCACTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8398.39 Da        Isoelectric Point: 4.3719

>AT162868 WP_000450523.1 NZ_CP056166:c74334-74107 [Escherichia marmotae]
METTVFLSNRSQAVRLPKAVALPEDVKKVDVIAVGRTRIITPAGESWDSWFDGDSVSADFMNDREQPAVQERESF

Download         Length: 228 bp

>AT162868 NZ_CP072146:3783380-3783676 [Rhizobium sp. K1/93]
ATGAAGCACATTCTCCCACCGGTGCATCCGGGTGAAATCCTTCGGGAGGAGTATCTGGCACCGCTTAAAATGAGCGCCGG
TGCCCTCGCGCGCAAGCTGAACGTCCCGCGAACGCGCATCGAGCGTCTGGTCGCCGAGGAAACGCCGGTGACCATCGATA
CCGCGTTGCGGTTGGCCCGCTTTTTCGACACGACGCCGGAGTTTTGGATGAATATGCAAACTGGCTACGAACTGAAGCGC
CAGGCGGAGGAAAAGAGAGCCGAGATCGCCGCTATCCCAGTCCTCCATGTCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6LFS1

References