Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3816615..3817266 Replicon chromosome
Accession NZ_CP056165
Organism Escherichia marmotae strain RHBSTW-00777

Toxin (Protein)


Gene name cptA Uniprot ID A0A370V2T3
Locus tag HV276_RS18515 Protein ID WP_000244789.1
Coordinates 3816615..3817019 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U9H610
Locus tag HV276_RS18520 Protein ID WP_000354045.1
Coordinates 3817000..3817266 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV276_RS18495 3812579..3814312 - 1734 WP_000813173.1 single-stranded-DNA-specific exonuclease RecJ -
HV276_RS18500 3814318..3815028 - 711 WP_000715232.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV276_RS18505 3815053..3815949 - 897 WP_000806649.1 site-specific tyrosine recombinase XerD -
HV276_RS18510 3816060..3816581 + 522 WP_001055874.1 flavodoxin FldB -
HV276_RS18515 3816615..3817019 - 405 WP_000244789.1 protein YgfX Toxin
HV276_RS18520 3817000..3817266 - 267 WP_000354045.1 FAD assembly factor SdhE Antitoxin
HV276_RS18525 3817519..3818499 + 981 WP_000886070.1 tRNA-modifying protein YgfZ -
HV276_RS18530 3818646..3819305 - 660 WP_001517030.1 hemolysin III family protein -
HV276_RS18535 3819468..3819779 - 312 WP_001182960.1 N(4)-acetylcytidine aminohydrolase -
HV276_RS18540 3819824..3821257 + 1434 WP_001517031.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15987.93 Da        Isoelectric Point: 11.5202

>T162867 WP_000244789.1 NZ_CP056165:c3817019-3816615 [Escherichia marmotae]
VVLWQSELRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWLVLLSLVVFDCVRSQRRINSRQGEIRLLMDGRLRWQGQ
EWSIVKTPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIR

Download         Length: 405 bp

>T162867 NZ_CP072146:c3709814-3709554 [Rhizobium sp. K1/93]
ATGAAAATTACGTGGGACGAGCGCAAGCGGCTCGCAAATTTCGACAAGCACGGCCTCGATTTCGCCGAACTCGACGCGGA
TTTCTTTCTTGCAGCTCTTTTGCAACCGGCAAAACTCGGACGGTTCAAGGCCATCGGGCGACGACATGACGGTACGACCG
CAGTCATCTTCGCCGTTCTCGGGCGCGAGGCGGTCTCGGTAATATCGATGCGGCCTGCGCACAAAGCCGAAAGGAGCCTG
TTGAATGACAAAGAAAACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10533.09 Da        Isoelectric Point: 5.1496

>AT162867 WP_000354045.1 NZ_CP056165:c3817266-3817000 [Escherichia marmotae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT162867 NZ_CP072146:c3709570-3709262 [Rhizobium sp. K1/93]
ATGACAAAGAAAACTGAAATGCGGAGCGACTTCCAGAATGGCCGGGGCTATTCAGACCAGGATTGGGAGGAGGTTTCCGA
CAATCCTGAATGGACCGAGGAAGACTTCAAGAATGCCCGTCCGTTTGCCGAGGTTTTCCCGGATCTGGCGGAAAGCATTC
GCCGGGCCCGGGGGCGACCGGCGGTCGAGGCGCCGAAGCGGCAAATCTCGCTGCGGCTCGATCCCGATGTCATCGATGCC
TTCAAGGCCACCGGCAAGGGCTGGCAGAGCCGTATCAACGAGGCTTTGCGCAAGGCGGCCAAAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A370V2T3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H610

References