Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 422518..423014 Replicon chromosome
Accession NZ_CP056165
Organism Escherichia marmotae strain RHBSTW-00777

Toxin (Protein)


Gene name ghoT Uniprot ID A0A7U9DCZ4
Locus tag HV276_RS02010 Protein ID WP_001173345.1
Coordinates 422841..423014 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A7U9DAJ1
Locus tag HV276_RS02005 Protein ID WP_001517605.1
Coordinates 422518..422814 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV276_RS01985 419250..419969 - 720 WP_000611294.1 two-component system response regulator DcuR -
HV276_RS01990 419966..421597 - 1632 WP_001216442.1 sensor histidine kinase -
HV276_RS01995 421776..422006 + 231 WP_000371696.1 (4Fe-4S)-binding protein -
HV276_RS02000 422018..422290 + 273 WP_000405652.1 N-acetyltransferase -
HV276_RS02005 422518..422814 + 297 WP_001517605.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
HV276_RS02010 422841..423014 + 174 WP_001173345.1 type V toxin-antitoxin system toxin GhoT Toxin
HV276_RS02015 423133..424650 - 1518 WP_001295074.1 lysine--tRNA ligase -
HV276_RS02020 424887..426344 - 1458 WP_001517606.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 422518..431866 9348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(7-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T162845 WP_001173345.1 NZ_CP056165:422841-423014 [Escherichia marmotae]
MALFSKILIFYVIGVNISFVIIWFLSHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T162845 NZ_CP072141:1427448-1427777 [Rhizobium sp. L51/94]
GTGGATCGCGGAGACATCTGGCACGTCGATCTAGAACCGATCCGTGGACGTGAACAGGCTGGCGCGCGGTATGTGCTGGT
GGTTACCAAGAAAAGCTTCAATGCCATCGGCACGCCGATAGTGGTGCCTATAACGACCGGCGGTGAGTTTGCCCGTTTCA
AAGGATTTGCCGTGTCGTTGTCCGGCGCGGGAACGCGGAGTTCGGGTGTGATCCTGTGCAATCAGCTGCGGTCGCTCGAC
CTCAGGGCGCGCGGCGGGAAATACGTGGAAAGTGTGCCGGATTTCATCATGTTCGAAGTGCTTGCCCGGATCACTATATT
CTTCGACTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11568.18 Da        Isoelectric Point: 4.0994

>AT162845 WP_001517605.1 NZ_CP056165:422518-422814 [Escherichia marmotae]
MEGINRFKTYVVSFDYPSSYYSVFLRLRSLMYDMDFSSIVADEYGIPRQLNENAFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMIVDDYFRQFYK

Download         Length: 297 bp

>AT162845 NZ_CP072141:1427191-1427448 [Rhizobium sp. L51/94]
ATGGCGACATCGACACTTCGCAATGTGGGAGGCTCTGTCATGATGACGATCCCGAAAGCTGTAGTTGATGAGTTGGGACT
GACAGCCAATACCAAGGTCGAGGTATTGGCAGAGGATGGGCGCGTCGTTGCGGTTCCGCACAAGCGGCCGAAGTACACGC
TCGATGAGCTTTTGGCGCAGTGCGATCTTGATGCACCGTTTACAGAGGAAGATCGGGAATGGCTCGATGATGCACCGTCT
GGCCGAGAGGTCATCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DCZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DAJ1

References