Detailed information of TA system TA162844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 52603..53143
• Replicon: plasmid pRHBSTW-00814_2
• Accession: NZ_CP056160
• Organism: Escherichia marmotae strain RHBSTW-00814

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HV284_RS24345
• Protein ID: WP_181475209.1
• Coordinates: 52603..52863 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: E1QMW3
• Locus tag: HV284_RS24350
• Protein ID: WP_000079941.1
• Coordinates: 52874..53143 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV284_RS24315	48161..48307	+	147	WP_157921632.1	hypothetical protein	-
HV284_RS24320	48447..48839	-	393	WP_097468732.1	mobilization protein MobC	-
HV284_RS24325	49031..49366	+	336	WP_000045231.1	mobilization protein	-
HV284_RS24330	49450..51384	+	1935	WP_181475202.1	relaxase/mobilization nuclease domain-containing protein	-
HV284_RS24335	51495..51698	+	204	WP_097468730.1	type II toxin-antitoxin system VapB family antitoxin	-
HV284_RS24340	51695..52069	+	375	WP_181475203.1	PIN domain-containing protein	-
HV284_RS24345	52603..52863	-	261	WP_181475209.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV284_RS24350	52874..53143	-	270	WP_000079941.1	hypothetical protein	Antitoxin
HV284_RS24355	53340..53774	-	435	Protein_71	hypothetical protein	-
HV284_RS24360	53771..53902	-	132	Protein_72	transposase	-
HV284_RS24365	54664..54987	+	324	WP_097468736.1	transcriptional regulator	-
HV284_RS24370	55326..55844	+	519	WP_097468728.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	faeC / faeD / faeE / faeF / faeH / faeI / faeJ / papC / papH / papH / papC	1..116663	116663

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10062.51 Da
• Isoelectric Point: 8.4795

>T162844 WP_181475209.1 NZ_CP056160:c52863-52603 [Escherichia marmotae]
MVASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAEQPYKGRHGRVEGTRELVIHPHFVLVYEVDNQWGKVYILRVLH
TAQKWP

Nucleotide

• Length: 261 bp

>T162844 NZ_CP072140:c7871-7494 [Agrobacterium sp. S7/73]
ATGAAGCAGGAAGAACGTCCGCTTGAGTGGATTGGCAGCAGCTACAAGGACCTGATGCAGCTTCCGGCCGATGTGCGGAA
GTCGGTCGGCTTCGCCCTGCATTTCGCGCAGCACGGCGAACAGCACCCGGCGTCAAAGGTGCTCAAAGGTTTTGGCGGCG
CTGGCGTGTTGGAAGTGGTCGAGAACGATGTGGGAGGCACATACCGGGCCGTCTACACGGTCCGGTATGAGGAAGCGGTG
TTCGTGCTGCATTGCTTCCAGAAGAAGAGCAAGAGCGGCATCGCCACGCCGAAAGAGGACATGGATGTTATCCGAGCGCG
GCTCAAGGTAGCCGAGGCTATAGCCAAGGAGATGAGAGATGCAAACGCGCGTCGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10252.58 Da
• Isoelectric Point: 7.2057

>AT162844 WP_000079941.1 NZ_CP056160:c53143-52874 [Escherichia marmotae]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Nucleotide

• Length: 270 bp

>AT162844 NZ_CP072140:c7513-7178 [Agrobacterium sp. S7/73]
ATGCAAACGCGCGTCGTTAATGGAATCGAGGTTACGACCAGTTCCGGCAATGTCTTTGCCGATCTCGGTCTACCTGACGC
CGACAAGCTCAAGGTGAAATCCGGCCTGATGATCGAAATCACCAAGGCCGTGCGGAGGCTTGGACTGACACAGGAGGAAG
CGGGGCGGCGCATGGGACTTCCACAGCCGAAGGTGTCAGCCCTGTTGCGTGGCGACTTCACCAATCTGTCAGAGCGCAAA
CTGATGGATGCCCTGAACCGCCTTGGCTACGATATCGAGATCAGGGTGCGGCCTACGGCCGATCCGGTCGGGCACCTGAC
GCTTGCGGTTGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A629TXC5