Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 51495..52069 Replicon plasmid pRHBSTW-00814_2
Accession NZ_CP056160
Organism Escherichia marmotae strain RHBSTW-00814

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV284_RS24340 Protein ID WP_181475203.1
Coordinates 51695..52069 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HV284_RS24335 Protein ID WP_097468730.1
Coordinates 51495..51698 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV284_RS24305 46563..47413 + 851 Protein_61 DUF4942 domain-containing protein -
HV284_RS24310 47458..47628 - 171 WP_123007493.1 helix-turn-helix domain-containing protein -
HV284_RS24315 48161..48307 + 147 WP_157921632.1 hypothetical protein -
HV284_RS24320 48447..48839 - 393 WP_097468732.1 mobilization protein MobC -
HV284_RS24325 49031..49366 + 336 WP_000045231.1 mobilization protein -
HV284_RS24330 49450..51384 + 1935 WP_181475202.1 relaxase/mobilization nuclease domain-containing protein -
HV284_RS24335 51495..51698 + 204 WP_097468730.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HV284_RS24340 51695..52069 + 375 WP_181475203.1 PIN domain-containing protein Toxin
HV284_RS24345 52603..52863 - 261 WP_181475209.1 type II toxin-antitoxin system RelE/ParE family toxin -
HV284_RS24350 52874..53143 - 270 WP_000079941.1 hypothetical protein -
HV284_RS24355 53340..53774 - 435 Protein_71 hypothetical protein -
HV284_RS24360 53771..53902 - 132 Protein_72 transposase -
HV284_RS24365 54664..54987 + 324 WP_097468736.1 transcriptional regulator -
HV284_RS24370 55326..55844 + 519 WP_097468728.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - faeC / faeD / faeE / faeF / faeH / faeI / faeJ / papC / papH / papH / papC 1..116663 116663


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-114)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13902.30 Da        Isoelectric Point: 6.8603

>T162843 WP_181475203.1 NZ_CP056160:51695-52069 [Escherichia marmotae]
MILVDTSVWVDHFKNKNDTLIQLLQSDFVLMHPMILAEIACGTPPAPRQQTLSDLDLLPKSHQATITEVLAFIENEKLFG
LGCGLVDITLLASTRITPGAKIWTLDKRLSRLAKRLNVEYQPVH

Download         Length: 375 bp

>T162843 NZ_CP072139:43930-44223 [Agrobacterium sp. S7/73]
GTGAAACTTACTTGGTCTGCGTTCGCGTTATCGGATCGCGACGCCATCTTCACATACATTGAGGCAGATAATCCTGCGGC
CGCCGTTCTGGTCGACGAACGGATAGTCGCAGCCTCACGTCGCTTGCTCGATTTTCCCGCCAGCGGCCGTGTTGGTAGAA
TTGCCGGTACACGCGAACTCGTCATCAACGGCACGCCCTACGTAGCTGTTTATGCCGTTACCGACACGACAGTTCGAATT
CTTCGTGTATTGCATGGCGCGCAGGAATGGCCAGAGTCTGTGCCGATAAGCTAA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7369.43 Da        Isoelectric Point: 4.9987

>AT162843 WP_097468730.1 NZ_CP056160:51495-51698 [Escherichia marmotae]
MRTTVTIDDALYAQALEMADPGMDKSDIFREAVKTFIRVQAAKRLASLGGTAPDMEITPRRRGDVAE

Download         Length: 204 bp

>AT162843 NZ_CP072139:43625-43933 [Agrobacterium sp. S7/73]
ATGGCCGCAAACGCACTTGTCCAAACACGTATTGATGCCGAGGTTCGGGATCGTGCCTCTGCCGTTCTTGAGAGCATGGG
CCTTACGGTATCCGATGCGGTCCGTATATTGCTTACACGGACTGCCAACGAAGGGGCGCTCCCCCTTGAGCTCCTTTCGG
GGAGTGAGGCTCATGACGTTTGGTTTCGCAACAAGGTGCTCGAAGCGCTAAACGATACTCGCCCGGACGTATCCGACGAC
GAGGTTGAGGCGCATTTTGCCGAACGTCGAGCGGCTGCCCGTCTTAAAGCTGGTGCGCTCAAATCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References