Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4084441..4085092 Replicon chromosome
Accession NZ_CP056159
Organism Escherichia marmotae strain RHBSTW-00814

Toxin (Protein)


Gene name cptA Uniprot ID A0A370V2T3
Locus tag HV284_RS19815 Protein ID WP_000244789.1
Coordinates 4084688..4085092 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U9H610
Locus tag HV284_RS19810 Protein ID WP_000354045.1
Coordinates 4084441..4084707 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV284_RS19790 4080450..4081883 - 1434 WP_001517031.1 6-phospho-beta-glucosidase BglA -
HV284_RS19795 4081928..4082239 + 312 WP_001182960.1 N(4)-acetylcytidine aminohydrolase -
HV284_RS19800 4082402..4083061 + 660 WP_001517030.1 hemolysin III family protein -
HV284_RS19805 4083208..4084188 - 981 WP_000886070.1 tRNA-modifying protein YgfZ -
HV284_RS19810 4084441..4084707 + 267 WP_000354045.1 FAD assembly factor SdhE Antitoxin
HV284_RS19815 4084688..4085092 + 405 WP_000244789.1 protein YgfX Toxin
HV284_RS19820 4085126..4085647 - 522 WP_001055874.1 flavodoxin FldB -
HV284_RS19825 4085758..4086654 + 897 WP_000806649.1 site-specific tyrosine recombinase XerD -
HV284_RS19830 4086679..4087389 + 711 WP_000715232.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV284_RS19835 4087395..4089128 + 1734 WP_000813173.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15987.93 Da        Isoelectric Point: 11.5202

>T162841 WP_000244789.1 NZ_CP056159:4084688-4085092 [Escherichia marmotae]
VVLWQSELRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWLVLLSLVVFDCVRSQRRINSRQGEIRLLMDGRLRWQGQ
EWSIVKTPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIR

Download         Length: 405 bp

>T162841 NZ_CP072138:449923-450216 [Agrobacterium sp. S7/73]
ATGCCATTTAGCCTATCTGTCCAAGCGGAAGAGGATATTATTTCCATTGCAGAAGAAGGCATCCGCATCTTCGGAGCACT
AGTCGCCAGACAATATCACGATGAGCTTTTTGCCTTGCTCGAGCTCATCGCCACCAACCCAAGAATGGCACGCGAACGCC
ATGAGATTTCTCCTCCTGTCAGGATCCATCCTTTCAAGGCTCACCTTGTCGTGTACCGCATCATTGAAGACGGGAGCGTA
TTCATCATCCGCATACGGCACAGCCATGAAGATTGGGCGGGAGATTCTTTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10533.09 Da        Isoelectric Point: 5.1496

>AT162841 WP_000354045.1 NZ_CP056159:4084441-4084707 [Escherichia marmotae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT162841 NZ_CP072138:449669-449923 [Agrobacterium sp. S7/73]
ATGGCGACGATGAATGTATCCCTGCCAGACCCAATGAAAGATTGGGTTGAAGCACAGGCCAAGACTGGTCGATACTCGAA
TGCGAGCGATTATGTCCGGGACCTGATCCGCAGAGACCAAGCGCGTACGGACAAGATTGCCGAGATGCAGCGATTTGTCG
ACGACGGGATCAGAAGCGGAGTTGGGAGCCGTTCAACGGAAGAGTTGTTTGCTTTAGCCACTTCTCGAGCTGACATCAGC
CGCGGACGCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A370V2T3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H610

References