Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3919445..3920277 Replicon chromosome
Accession NZ_CP056159
Organism Escherichia marmotae strain RHBSTW-00814

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HV284_RS19005 Protein ID WP_170898214.1
Coordinates 3919445..3919819 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV284_RS19010 Protein ID WP_089639763.1
Coordinates 3919909..3920277 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV284_RS18975 3915755..3916510 + 756 WP_181474345.1 IS21-like element ISEc10 family helper ATPase IstB -
HV284_RS18980 3916569..3916658 - 90 Protein_3706 restriction endonuclease subunit M -
HV284_RS18985 3916891..3918087 + 1197 WP_181474346.1 IS110 family transposase -
HV284_RS18990 3918115..3918666 - 552 Protein_3708 DUF4942 domain-containing protein -
HV284_RS18995 3918751..3918948 - 198 WP_000772034.1 DUF957 domain-containing protein -
HV284_RS19000 3918960..3919448 - 489 WP_170898215.1 hypothetical protein -
HV284_RS19005 3919445..3919819 - 375 WP_170898214.1 TA system toxin CbtA family protein Toxin
HV284_RS19010 3919909..3920277 - 369 WP_089639763.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV284_RS19015 3920327..3920971 - 645 WP_181474347.1 antitoxin of toxin-antitoxin stability system -
HV284_RS19020 3920990..3921211 - 222 WP_000692312.1 DUF987 domain-containing protein -
HV284_RS19025 3921280..3921756 - 477 WP_181474348.1 RadC family protein -
HV284_RS19030 3921772..3922242 - 471 WP_181474349.1 antirestriction protein -
HV284_RS19035 3922336..3922581 - 246 WP_000680586.1 hypothetical protein -
HV284_RS19040 3922581..3923399 - 819 WP_001234698.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14064.16 Da        Isoelectric Point: 8.7426

>T162840 WP_170898214.1 NZ_CP056159:c3919819-3919445 [Escherichia marmotae]
MKTLPDTLIREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T162840 NZ_CP072138:c319633-319250 [Agrobacterium sp. S7/73]
GTGATCCTGGTAGACACCTCGATCTGGATAGATCATTTTCGATACGATGACTCAGAACTACGAAAAATCATCAATGATGA
CCAGCTGCTCTGCCACCCATTCGTTGTAGGCGAATTGGCGCTCGGCAGCTTAAGAGAGCGGGCTGCAGTTTTAGAATTCC
TAGCAGCTCAACGCGAGGCGCTAATCGCGACCCATGCAGAAGTAATGACGATCATTGATCGTCATTCGATATTCAGCATG
GGGATTGGTTACACAGATGCGCATTTACTTACTTCAACGTTGCTCGACCGGCGATCAAGCTTGTGGACAAGAGATAAGCG
CCTAGCGGCCGCAGCGCAAAAAGTTGGTGCGGCACTTTACCCGCACGCGCACGCCTCTCATTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13625.37 Da        Isoelectric Point: 5.8746

>AT162840 WP_089639763.1 NZ_CP056159:c3920277-3919909 [Escherichia marmotae]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTMTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT162840 NZ_CP072138:c319830-319630 [Agrobacterium sp. S7/73]
ATGCGATCAACCATAAATATCGACGACAATCTTATGGAACGGGCCAAGTCCCTCACGGGCACCAAGGAAACAGCAGCTCT
CGTGCGGCAAGCGCTGGAGACACTCGTGCGTGTGGAATCCGGCAAACGGCTGATCGCGCTTGGCGGCTCTATGCCTGAGG
CTGAAGCGTCGCCTCGCCGACGGAGCGACGTGGCAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References