Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2674921..2675417 Replicon chromosome
Accession NZ_CP056159
Organism Escherichia marmotae strain RHBSTW-00814

Toxin (Protein)


Gene name ghoT Uniprot ID A0A7U9DCZ4
Locus tag HV284_RS13140 Protein ID WP_001173345.1
Coordinates 2674921..2675094 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A7U9DAJ1
Locus tag HV284_RS13145 Protein ID WP_001517605.1
Coordinates 2675121..2675417 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV284_RS13130 2671591..2673048 + 1458 WP_001517606.1 dipeptide/tripeptide permease DtpC -
HV284_RS13135 2673285..2674802 + 1518 WP_001295074.1 lysine--tRNA ligase -
HV284_RS13140 2674921..2675094 - 174 WP_001173345.1 type V toxin-antitoxin system toxin GhoT Toxin
HV284_RS13145 2675121..2675417 - 297 WP_001517605.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
HV284_RS13150 2675645..2675917 - 273 WP_000405652.1 N-acetyltransferase -
HV284_RS13155 2675929..2676159 - 231 WP_000371696.1 (4Fe-4S)-binding protein -
HV284_RS13160 2676338..2677969 + 1632 WP_001216442.1 sensor histidine kinase -
HV284_RS13165 2677966..2678685 + 720 WP_000611294.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(7-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T162838 WP_001173345.1 NZ_CP056159:c2675094-2674921 [Escherichia marmotae]
MALFSKILIFYVIGVNISFVIIWFLSHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T162838 NZ_CP072136:2296712-2296963 [Agrobacterium sp. S7/73]
GTGATCTGGACAATTGAATACGATGTTCTTGTCCAGAAAGAGATGCGGAAAATCGATCCGCAGACGCGTCAGCGTATCCG
AGTAGCGGCGCTCGACAATCCCCGCCAGACAGGTGCCGCCCTGCAAGGCTCAGAACTCGGCAGCTTCTGGCGTTACCGGG
TAGGCGATTACCGTATCATCTGCGATATACAGGACCACAAGCTTGTCGTGCTGGTGGTGGAAATTGGCCATCGCCGCGAA
ATCTACCGTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11568.18 Da        Isoelectric Point: 4.0994

>AT162838 WP_001517605.1 NZ_CP056159:c2675417-2675121 [Escherichia marmotae]
MEGINRFKTYVVSFDYPSSYYSVFLRLRSLMYDMDFSSIVADEYGIPRQLNENAFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMIVDDYFRQFYK

Download         Length: 297 bp

>AT162838 NZ_CP072136:2296501-2296728 [Agrobacterium sp. S7/73]
ATGAGCAAACAGACTGCCATCCGCCTGCCGGACGAGACCTATGAACGGCTGAAAGCGCTTTCCGAGCGCACGGGCCGTAC
GTCCGCATACTATATCCGCGAGGCGATTGAGAAACATATTGAGGATATGGAAGATCTCTATCTAGCCGAAGAGGCGACGC
GGCGCATCCAGCGCGGTGAATCAAAGGTGGTAAGCGCCGAGGAGTTCTGGCGTGATCTGGACAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DCZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DAJ1

References