Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 593723..594903 Replicon chromosome
Accession NZ_CP056159
Organism Escherichia marmotae strain RHBSTW-00814

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HV284_RS03110 Protein ID WP_181474713.1
Coordinates 593989..594903 (+) Length 305 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HV284_RS03105 Protein ID WP_181474712.1
Coordinates 593723..593989 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV284_RS03090 590399..591313 + 915 WP_001516366.1 bestrophin family protein -
HV284_RS03095 591317..592075 - 759 WP_061090837.1 trans-aconitate 2-methyltransferase -
HV284_RS03100 592503..593459 + 957 WP_181474711.1 hypothetical protein -
HV284_RS03105 593723..593989 + 267 WP_181474712.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HV284_RS03110 593989..594903 + 915 WP_181474713.1 HipA N-terminal domain-containing protein Toxin
HV284_RS03115 595311..596168 + 858 WP_181474714.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 305 a.a.        Molecular weight: 34380.77 Da        Isoelectric Point: 9.3665

>T162827 WP_181474713.1 NZ_CP056159:593989-594903 [Escherichia marmotae]
MPKLVTWMNNQRVGELTKLTNGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGVVTLLPEDETVTRPIMVWEKLTEARLEEVLTAYKADIPLGMIREEILMGSSEALRDRYDFM
KFQVFQWLIGSTDGHAKNFSVFIQAGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGRKTEIDKIYPRHFLA
TAKALKFPEVQMHEILSDFARMIPAALDNVKASLPADFPENVLTAIETNVLRLHGRLSREYGIK

Download         Length: 915 bp

>T162827 NZ_CP072130:287521-287796 [Klebsiella variicola]
ATGGAGCAGCAGGTTTTATCTTTACGTAATAAACAGCGCCACACGCTGGAGCAACTGTTTAAAATCCCTGTGCCACAGGG
CATTAAATGGGCCGACATTGAATCGCTAATTAAAGCGTTAGGCGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCATCCTTCGCCGGATACTGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10007.34 Da        Isoelectric Point: 4.5668

>AT162827 WP_181474712.1 NZ_CP056159:593723-593989 [Escherichia marmotae]
MMSFPMIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLSLSMTLCDTKNDSPES
TDQQDLEW

Download         Length: 267 bp

>AT162827 NZ_CP072130:287793-288152 [Klebsiella variicola]
ATGATCAAACCTAAAACGCCAAACTCAATGGAGATTGCCGGCCAGCCTGCCGTTATCAATTACGTGCCTGAGCTCAATGC
ATTCCGCGGTAAGTTCCTTGGATTATCAGGATATTGCGATTTTGTTTCCGATAGTATTCAAGGGTTACAACAGGAGGGCG
AGATATCATTACAGGAGTATCTCGCAGATTGTCATGAAGCGGGGATTGAGCCTTATGCTCACCCGGAAAAGATGAAAACC
TTCACGCTGCGCTATCCTGAGTCATTTGGCGAGCGTCTTAGCTCCGCCGCTGCGGAGGAGCAGGTTTCCGTAAATACCTG
GATCCTTGAGACGCTCAATGAACGTCTCAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References