Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 199349..199969 Replicon plasmid pRHBSTW-00844_2
Accession NZ_CP056156
Organism Enterobacter hormaechei strain RHBSTW-00844

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV295_RS22100 Protein ID WP_015571250.1
Coordinates 199349..199567 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV295_RS22105 Protein ID WP_006809850.1
Coordinates 199595..199969 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV295_RS22070 195361..195621 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HV295_RS22075 195624..195764 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV295_RS22080 195761..196471 - 711 WP_047051118.1 GNAT family N-acetyltransferase -
HV295_RS22085 196573..198033 + 1461 WP_047051117.1 PLP-dependent aminotransferase family protein -
HV295_RS22090 198005..198472 - 468 WP_017383209.1 membrane protein -
HV295_RS22095 198589..199140 - 552 WP_017694396.1 maltose O-acetyltransferase -
HV295_RS22100 199349..199567 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV295_RS22105 199595..199969 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV295_RS22110 200479..203625 - 3147 WP_047051116.1 multidrug efflux RND transporter permease subunit AcrB -
HV295_RS22115 203648..204841 - 1194 WP_047051115.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - IlpA / gmhA/lpcA / acrB / acrA / fimC / fimD / fimH / gtrB / gtrA / lpxD / lpxA 1..361638 361638


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T162816 WP_015571250.1 NZ_CP056156:c199567-199349 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T162816 NZ_CP072119:2390226-2390329 [Klebsiella michiganensis]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT162816 WP_006809850.1 NZ_CP056156:c199969-199595 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT162816 NZ_CP072119:c2390336-2390168 [Klebsiella michiganensis]
AACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGCGACAAAAGTG
GACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References