Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1410453..1411250 Replicon chromosome
Accession NZ_CP056155
Organism Enterobacter hormaechei strain RHBSTW-00844

Toxin (Protein)


Gene name KacT Uniprot ID A0A4Q2R3N2
Locus tag HV295_RS06640 Protein ID WP_032670168.1
Coordinates 1410729..1411250 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID F5RT92
Locus tag HV295_RS06635 Protein ID WP_001303459.1
Coordinates 1410453..1410722 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV295_RS06605 1405993..1406352 + 360 WP_040117469.1 helix-turn-helix transcriptional regulator -
HV295_RS06610 1406678..1407919 + 1242 WP_047051685.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
HV295_RS06615 1407952..1408179 - 228 WP_006809324.1 YccJ family protein -
HV295_RS06620 1408198..1408794 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
HV295_RS06625 1409186..1409356 + 171 WP_001273664.1 general stress protein -
HV295_RS06630 1409473..1410378 + 906 WP_047051684.1 DMT family transporter -
HV295_RS06635 1410453..1410722 + 270 WP_001303459.1 DUF1778 domain-containing protein Antitoxin
HV295_RS06640 1410729..1411250 + 522 WP_032670168.1 GNAT family N-acetyltransferase Toxin
HV295_RS06645 1411309..1412631 - 1323 WP_048982825.1 pyrimidine utilization transport protein G -
HV295_RS06650 1412653..1413144 - 492 WP_047052688.1 pyrimidine utilization flavin reductase protein F -
HV295_RS06655 1413157..1413747 - 591 WP_047052687.1 malonic semialdehyde reductase -
HV295_RS06660 1413757..1414557 - 801 WP_047052686.1 pyrimidine utilization protein D -
HV295_RS06665 1414565..1414951 - 387 WP_032670161.1 pyrimidine utilization protein C -
HV295_RS06670 1414963..1415652 - 690 WP_047052685.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19437.18 Da        Isoelectric Point: 7.4318

>T162801 WP_032670168.1 NZ_CP056155:1410729-1411250 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLVRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

>T162801 NZ_CP072116:2436141-2436248 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10248.70 Da        Isoelectric Point: 5.8836

>AT162801 WP_001303459.1 NZ_CP056155:1410453-1410722 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT162801 NZ_CP072116:c2436325-2436265 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q2R3N2

Antitoxin

Source ID Structure
AlphaFold DB A0A7D7BCZ2

References