Detailed information of TA system TA162799

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 642782..643461
• Replicon: chromosome
• Accession: NZ_CP056155
• Organism: Enterobacter hormaechei strain RHBSTW-00844

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: HV295_RS03125
• Protein ID: WP_023326100.1
• Coordinates: 643120..643461 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV295_RS03120
• Protein ID: WP_023326101.1
• Coordinates: 642782..643099 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV295_RS03075	638220..639041	+	822	WP_023326105.1	DUF945 domain-containing protein	-
HV295_RS03080	639258..639959	+	702	WP_023326104.1	WYL domain-containing protein	-
HV295_RS03085	640000..640236	+	237	WP_001144031.1	hypothetical protein	-
HV295_RS03090	640236..640679	+	444	WP_000824223.1	hypothetical protein	-
HV295_RS03095	640702..641169	+	468	WP_001547765.1	hypothetical protein	-
HV295_RS03100	641246..641485	+	240	WP_000194654.1	DUF905 domain-containing protein	-
HV295_RS03105	641583..642041	+	459	WP_000211838.1	antirestriction protein	-
HV295_RS03110	642057..642533	+	477	WP_023326103.1	RadC family protein	-
HV295_RS03115	642542..642763	+	222	WP_023326102.1	DUF987 domain-containing protein	-
HV295_RS03120	642782..643099	+	318	WP_023326101.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV295_RS03125	643120..643461	+	342	WP_023326100.1	TA system toxin CbtA family protein	Toxin
HV295_RS03135	643823..644329	+	507	WP_032649590.1	G/U mismatch-specific DNA glycosylase	-
HV295_RS03140	644419..646263	-	1845	WP_006812010.1	RNA polymerase sigma factor RpoD	-
HV295_RS03145	646417..648162	-	1746	WP_003862574.1	DNA primase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	605871..643461	37590

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (2-112)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12990.98 Da
• Isoelectric Point: 9.9961

>T162799 WP_023326100.1 NZ_CP056155:643120-643461 [Enterobacter hormaechei]
MKPQSAATSRAVKPCLTPVAIWQILLTRLLEQHYGLTLNDTPFSEERVIQEHIDTGISLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQVTGLLRQSRKNSVR

Nucleotide

• Length: 342 bp

>T162799 NZ_CP072116:1251436-1251624 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11899.58 Da
• Isoelectric Point: 6.9463

>AT162799 WP_023326101.1 NZ_CP056155:642782-643099 [Enterobacter hormaechei]
MSNITWGLRRDITPRLGARLVQEGNRLHYLADRASMTGKFSDAECQKLDETFPHFISQMESMLTTGELNPLHVHCVTLYH
TGFTCEADTLGSCGYVYIAIYPTKR

Nucleotide

• Length: 318 bp

>AT162799 NZ_CP072116:1251147-1251407 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA