Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 114577..115103 Replicon plasmid pRHBSTW-00853_2
Accession NZ_CP056151
Organism Klebsiella grimontii strain RHBSTW-00853

Toxin (Protein)


Gene name relE Uniprot ID A0A7H4N9C7
Locus tag HV299_RS29705 Protein ID WP_004118126.1
Coordinates 114577..114864 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HV299_RS29710 Protein ID WP_000534858.1
Coordinates 114864..115103 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV299_RS29685 109770..110618 - 849 WP_004118114.1 oxidoreductase -
HV299_RS29690 110983..112239 + 1257 WP_004118116.1 MFS transporter -
HV299_RS29695 112452..113717 + 1266 WP_004118118.1 hypothetical protein -
HV299_RS29700 114344..114505 - 162 WP_004118124.1 type I toxin-antitoxin system Hok family toxin -
HV299_RS29705 114577..114864 - 288 WP_004118126.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HV299_RS29710 114864..115103 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HV299_RS29715 115233..116393 - 1161 WP_004118128.1 IS30 family transposase -
HV299_RS29720 116648..117463 + 816 WP_004118130.1 SDR family oxidoreductase -
HV299_RS29725 117493..118254 + 762 WP_004118132.1 SDR family NAD(P)-dependent oxidoreductase -
HV299_RS29730 118297..119304 + 1008 WP_004118134.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..201629 201629
- flank IS/Tn - - 115233..116393 1160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11223.16 Da        Isoelectric Point: 10.1967

>T162793 WP_004118126.1 NZ_CP056151:c114864-114577 [Klebsiella grimontii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLAEVLESPRIDANKLRGMHDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T162793 NZ_CP072113:c3088325-3087897 [Yimella sp. cx-51]
ATGAAGATCGTCGACACGAATGTCCTCTTGTATGCGGTCAATGCCGGATCTGCGCCTCACAGTGCGTGTCGCGCGTGGCT
GATCGATGCACTAGAGGGCGCCGAAGGAGTCGGTTTGCCCTGGGTGAGTCTGCTGGGGTTTATCCGCATTTCGACCAACC
CGCGGATCTTTGAGCACCCGCTGACATCTGCCCAGGCAACCGACCTCGTTCAGGCCTGGCTTGCACAGCCGAGCGCACTC
ACGCCCGAGCCGACGCCCCGGCACGCGTCAATCCTGGCTGGCCTCGTGGCGCCGTCAGGCGTCGCCGGAAACCTCACGAC
CGATGCGCATCTTGCGGCGCTCGCGCTCGAGTACGACGCCGAGGTCGTGACGATGGACCGTGATTTCGAGCGGTTCGGCG
TGCGTGTCGTCGTCCCCGGCAGACTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT162793 WP_000534858.1 NZ_CP056151:c115103-114864 [Klebsiella grimontii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT162793 NZ_CP072113:c3088576-3088322 [Yimella sp. cx-51]
ATGGCACGTACCACTGTGACGCTGGAGTCGGACGTCGAGGCGATGATCGCGCGACTGATGGCTGAGCGTGGTATCTCCTT
CAAGGAAGCCCTGAACCAGGCGGTTCGTCGCGGACTGTCGTCGGGTGTTCGGGCCGATTTCGTCATGCCCAGCTTCGACA
TGGGCTCGCCACTCGTCGACCTCACCCACGCCTCGCGTATCGCCGGCGAACTCGAGGACGAGGAAATCGTCCGGGAGTTG
CGCGTCGGCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4N9C7

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References