Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 93055..93791 Replicon plasmid pRHBSTW-00853_2
Accession NZ_CP056151
Organism Klebsiella grimontii strain RHBSTW-00853

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV299_RS29580 Protein ID WP_049083183.1
Coordinates 93055..93537 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV299_RS29585 Protein ID WP_049083184.1
Coordinates 93525..93791 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV299_RS29555 88118..89086 + 969 WP_177939556.1 IS5 family transposase -
HV299_RS29560 89337..89747 + 411 WP_040210104.1 hypothetical protein -
HV299_RS29565 90035..90607 + 573 WP_032676095.1 recombinase family protein -
HV299_RS29570 90616..91434 + 819 WP_023307220.1 abortive infection family protein -
HV299_RS29575 91505..92848 - 1344 WP_077259867.1 ISNCY family transposase -
HV299_RS29580 93055..93537 - 483 WP_049083183.1 GNAT family N-acetyltransferase Toxin
HV299_RS29585 93525..93791 - 267 WP_049083184.1 DUF1778 domain-containing protein Antitoxin
HV299_RS29590 93878..94657 + 780 WP_176392677.1 hypothetical protein -
HV299_RS29595 94651..95348 - 698 Protein_109 IS1 family transposase -
HV299_RS29600 95403..95717 - 315 WP_074181342.1 hypothetical protein -
HV299_RS29605 95744..96145 - 402 WP_177343058.1 hypothetical protein -
HV299_RS29610 96314..96619 - 306 WP_004197633.1 type II toxin-antitoxin system toxin CcdB -
HV299_RS29615 96621..96839 - 219 WP_004197642.1 type II toxin-antitoxin system antitoxin CcdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..201629 201629
- inside IScluster/Tn - - 88118..98284 10166


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17326.90 Da        Isoelectric Point: 9.1188

>T162791 WP_049083183.1 NZ_CP056151:c93537-93055 [Klebsiella grimontii]
VGRITAPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

>T162791 NZ_CP072111:937492-937746 [Corynebacterium hindlerae]
ATGCTCCTCACTTGGGATGAGAATGCCTGGGAAGACTATCTGTGGTGGCAAGCGCACGACCGGAAAGTCTTGAAGCGGAT
CAATGCTCTAATCAAGGACATTGCCCGGAATGGCAACGAGGGAATAGGTAAGCCCGAGCCATTGAAACATGAATTTGCCG
GATTCTGGTCTCGGCGAATCACTGAAGAGCATCGCCTCGTCTACCGAGTGGTTGAAAACGACATCACTGTGCTGGCTTGT
CGTTATCACTATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10117.61 Da        Isoelectric Point: 4.6437

>AT162791 WP_049083184.1 NZ_CP056151:c93791-93525 [Klebsiella grimontii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDVQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT162791 NZ_CP072111:937232-937486 [Corynebacterium hindlerae]
ATGAAGACGATCAGTTACACCGAGTCGCGTGCGAATTATGCGCGGGTCTTGGACGACGTTGTCAATGATCGTGAGCCTGT
CACCATTACGCGAGCCGGGCACGAATCAGTCGTGATGATGTCCCTAGATGATTATTCGTCATTGCAGGAAACTGCTTATC
TGATGCGGTCACCGGCAAATGCTCGACGGCTTTTCGACGCGCTGGAGCGTGTGAAAGCTGGAGACGTAACAAAGCATGAG
CTCATCGAGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References