Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5954393..5955003 Replicon chromosome
Accession NZ_CP056150
Organism Klebsiella grimontii strain RHBSTW-00853

Toxin (Protein)


Gene name vapC Uniprot ID A0A9E1GAR7
Locus tag HV299_RS28635 Protein ID WP_049086919.1
Coordinates 5954393..5954767 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HV299_RS28640 Protein ID WP_077265771.1
Coordinates 5954764..5955003 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV299_RS28620 5951548..5952450 + 903 WP_004122548.1 formate dehydrogenase subunit beta -
HV299_RS28625 5952447..5953082 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
HV299_RS28630 5953426..5954355 + 930 WP_004132861.1 formate dehydrogenase accessory protein FdhE -
HV299_RS28635 5954393..5954767 - 375 WP_049086919.1 type II toxin-antitoxin system VapC family toxin Toxin
HV299_RS28640 5954764..5955003 - 240 WP_077265771.1 ribbon-helix-helix domain-containing protein Antitoxin
HV299_RS28645 5955209..5956126 + 918 WP_154915486.1 alpha/beta hydrolase -
HV299_RS28650 5956144..5957085 - 942 WP_004127112.1 fatty acid biosynthesis protein FabY -
HV299_RS28655 5957130..5957567 - 438 WP_004132870.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV299_RS28660 5957564..5958424 - 861 WP_004127107.1 virulence factor BrkB family protein -
HV299_RS28665 5958418..5959017 - 600 WP_024360709.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14111.45 Da        Isoelectric Point: 8.4571

>T162788 WP_049086919.1 NZ_CP056150:c5954767-5954393 [Klebsiella grimontii]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWMEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

>T162788 NZ_CP072110:c1728182-1727907 [Psychrosphaera ytuae]
GTGATTTATTGGGAAGAGCAATCGCTGATTGACCGAGAAAAAGTATTTGAATTTTTGTACGAGTTTAACCCATTAGCCGC
AGAAGCAACCGATGATACTATTGAAAAAAATGTGGAAGGCCTGTTGCTGCAACCTGAAATGGGAGTCGAGCGAGAAGGCA
TAGAGGGGCGCTTGTTAATAATTCCTGAAATATCAATGATCGTTTCATATTACTCCGACGGAAAAAATATAAGAGTAATG
AGAGTGCTTCACATGAAGCAAAAATTTCCAGGTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9307.51 Da        Isoelectric Point: 4.3253

>AT162788 WP_077265771.1 NZ_CP056150:c5955003-5954764 [Klebsiella grimontii]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEEGVEFERKLREEWQ

Download         Length: 240 bp

>AT162788 NZ_CP072110:c1728463-1728185 [Psychrosphaera ytuae]
ATGGATACTCGAATTCAATTCAGAATCGATGAAGAAGTCAAAAGGCTAGCGCAACAAATGGCAGAGAGCCAGGGGCGAAC
TATTAGTGACGCTTGTCGAGAGCTTACAGAGCAATTGGCTGAGCAGCAACGTCAAAAGTTATCTCATGACACTTGGCTGT
CGGAGCAGGTTAATTTAGCGTTTGAAAAGCTAGAAACAGGGAACACCAAGTTTGTTACTCATGAAGCTGCTAAGGAGTCT
ATGGCAGAACGGAAAGCAAAAATTAGACTTCGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References