Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4674720..4675339 Replicon chromosome
Accession NZ_CP056150
Organism Klebsiella grimontii strain RHBSTW-00853

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag HV299_RS22590 Protein ID WP_004099646.1
Coordinates 4675121..4675339 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag HV299_RS22585 Protein ID WP_004129911.1
Coordinates 4674720..4675094 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV299_RS22575 4669890..4671083 + 1194 WP_004136054.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV299_RS22580 4671106..4674252 + 3147 WP_004848339.1 multidrug efflux RND transporter permease subunit -
HV299_RS22585 4674720..4675094 + 375 WP_004129911.1 Hha toxicity modulator TomB Antitoxin
HV299_RS22590 4675121..4675339 + 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
HV299_RS22595 4675501..4676067 + 567 WP_004136050.1 maltose O-acetyltransferase -
HV299_RS22600 4676194..4676664 + 471 WP_004136048.1 YlaC family protein -
HV299_RS22605 4676639..4678093 - 1455 WP_098066517.1 PLP-dependent aminotransferase family protein -
HV299_RS22610 4678194..4678892 + 699 WP_154915349.1 GNAT family N-acetyltransferase -
HV299_RS22615 4678889..4679029 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV299_RS22620 4679029..4679292 - 264 WP_004129897.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T162785 WP_004099646.1 NZ_CP056150:4675121-4675339 [Klebsiella grimontii]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T162785 NZ_CP072063:16022-16594 [Bacillus mycoides]
TTGGCTAATAAAGATAATCCTAAATTTTACACTATTTCAACTAAATATATAGACTATCTAAGAGAAACAGATAGTAAAGT
ACCCTTTAATAAAGATGAACAGCATAGCAGACCGTATGTAGGCGTATTGGAAAAAATCAATGGTCATGATTATTTTGTGC
CTTTAACATCACGTAATGATAAAAATTTTAATAGTCAGGTCAGTGTAAAATTATTCGATAACGATAACCCTGAGAAGCGA
ATTGGAGTTTTATTAATAAATAACATGATTCCAGTCCCAGAAAAAGAGTGTAAAGAAATTGATATAGCAGAAAAAACGGC
GGCAGACCCTAAGTATGGTAATTTGATGTTAAAGCAGTATTTGTTTTTAAAAGAGAATATGGATCGAGTGTCTAATAAAG
TAGAAAAAATATATAAAGATGTATCTGTACAAGGGAAGCCTTCACAAAAACAGAAATTCATTAAAGGAGTTTGTTGTGAT
TTCCCTAAATTAGAAGGAAAATGCCAAGAATATAAAGAAAGAGATCAAGCTAGAAGGATAGCATATATGCGCCAAATGGG
GCGTGAGAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT162785 WP_004129911.1 NZ_CP056150:4674720-4675094 [Klebsiella grimontii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT162785 NZ_CP072063:15863-15959 [Bacillus mycoides]
GTAGCCTTACTTTAGTAGGCGCGAAAAAATTGGTGTAACTCTACCGTAGTGAGTACCAAAAAATTGGTGTAGCCTTACCG
TAGTAGGCGCAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HD25

References