Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1364807..1365544 Replicon chromosome
Accession NZ_CP056150
Organism Klebsiella grimontii strain RHBSTW-00853

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HV299_RS06545 Protein ID WP_038886251.1
Coordinates 1364807..1365187 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV299_RS06550 Protein ID WP_038886249.1
Coordinates 1365218..1365544 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV299_RS06520 1360664..1361575 + 912 WP_004135102.1 LysR family transcriptional regulator -
HV299_RS06525 1361872..1362276 + 405 WP_024358399.1 hypothetical protein -
HV299_RS06530 1362273..1363877 + 1605 WP_154915740.1 cell envelope biogenesis protein TolA -
HV299_RS06535 1364081..1364284 - 204 Protein_1283 integrase -
HV299_RS06540 1364649..1364810 - 162 WP_181499890.1 hypothetical protein -
HV299_RS06545 1364807..1365187 - 381 WP_038886251.1 TA system toxin CbtA family protein Toxin
HV299_RS06550 1365218..1365544 - 327 WP_038886249.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV299_RS06555 1365555..1366022 - 468 WP_181499891.1 DNA repair protein RadC -
HV299_RS06560 1366037..1366456 - 420 WP_181499892.1 antirestriction protein -
HV299_RS06565 1366587..1367030 - 444 WP_181499893.1 hypothetical protein -
HV299_RS06570 1367083..1367712 - 630 WP_181499894.1 hypothetical protein -
HV299_RS06575 1367718..1368419 - 702 WP_181499895.1 WYL domain-containing protein -
HV299_RS06580 1368632..1369507 - 876 WP_181499896.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13916.96 Da        Isoelectric Point: 7.9062

>T162775 WP_038886251.1 NZ_CP056150:c1365187-1364807 [Klebsiella grimontii]
MQTLPLPEPRAAEPCPSPVRIWQLLLAHLLDKHYGLMLNDTPFGDNSVIQAHINAGISLCDAVNFIVERYELVRTDHSRF
SLTERSSLIGAIDILRARRATGLIVSSGYSTITRITTGQYQGGKAQ

Download         Length: 381 bp

>T162775 NZ_CP072054:4238253-4238426 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12207.75 Da        Isoelectric Point: 5.9535

>AT162775 WP_038886249.1 NZ_CP056150:c1365544-1365218 [Klebsiella grimontii]
MHSEQWGLTCNKTPYFSVRLVQEGNRLHFLADRAGFTGDFSDDEALRLDQAFPLMMKQLEQMLSTGELNSRHQQRVTLNH
IGLTCEADTLGSHGYVYIAIYPSSTVTV

Download         Length: 327 bp

>AT162775 NZ_CP072054:4237929-4238225 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References