Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 738578..739331 Replicon chromosome
Accession NZ_CP056150
Organism Klebsiella grimontii strain RHBSTW-00853

Toxin (Protein)


Gene name yeeV Uniprot ID A0A097QYR4
Locus tag HV299_RS03555 Protein ID WP_025799003.1
Coordinates 738954..739331 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7T0E0C6
Locus tag HV299_RS03550 Protein ID WP_072269511.1
Coordinates 738578..738904 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV299_RS03530 733986..737141 + 3156 WP_080934392.1 AIDA repeat-containing protein -
HV299_RS03535 737364..737795 + 432 WP_088903392.1 antirestriction protein -
HV299_RS03540 737807..738286 + 480 WP_025798999.1 DNA repair protein RadC -
HV299_RS03545 738300..738521 + 222 WP_045888217.1 DUF987 domain-containing protein -
HV299_RS03550 738578..738904 + 327 WP_072269511.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV299_RS03555 738954..739331 + 378 WP_025799003.1 TA system toxin CbtA family protein Toxin
HV299_RS03560 739328..739819 + 492 WP_045888216.1 hypothetical protein -
HV299_RS03565 739848..740051 + 204 WP_025799007.1 DUF957 domain-containing protein -
HV299_RS03570 740133..740978 + 846 WP_025799009.1 DUF4942 domain-containing protein -
HV299_RS03580 741281..741787 + 507 WP_024358695.1 G/U mismatch-specific DNA glycosylase -
HV299_RS03585 741828..742490 - 663 WP_154916208.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 703615..740051 36436


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13993.97 Da        Isoelectric Point: 6.8515

>T162773 WP_025799003.1 NZ_CP056150:738954-739331 [Klebsiella grimontii]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR

Download         Length: 378 bp

>T162773 NZ_CP072054:c4006328-4005999 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12016.71 Da        Isoelectric Point: 6.4674

>AT162773 WP_072269511.1 NZ_CP056150:738578-738904 [Klebsiella grimontii]
IAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHGVTLYA
KGLTCNADTLGSCGYVYIAIYPTPATTE

Download         Length: 327 bp

>AT162773 NZ_CP072054:c4006666-4006349 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QYR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T0E0C6

References