Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 94730..95249 Replicon plasmid pRHBSTW-00872_2
Accession NZ_CP056149
Organism Enterobacter roggenkampii strain RHBSTW-00872

Toxin (Protein)


Gene name parE Uniprot ID A0A837F4A9
Locus tag HV308_RS23880 Protein ID WP_000277490.1
Coordinates 94730..95014 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6P1V8C3
Locus tag HV308_RS23885 Protein ID WP_000124732.1
Coordinates 95007..95249 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV308_RS23860 91321..92061 - 741 WP_000433876.1 O-antigen export ABC transporter ATP-binding protein RfbB -
HV308_RS23865 92061..92828 - 768 WP_015583927.1 ABC transporter permease -
HV308_RS23870 93388..94404 - 1017 WP_181548464.1 IS5-like element IS5 family transposase -
HV308_RS23875 94500..94592 + 93 Protein_80 DNA partition complex ParG -
HV308_RS23880 94730..95014 - 285 WP_000277490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV308_RS23885 95007..95249 - 243 WP_000124732.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HV308_RS23890 95822..96451 - 630 Protein_83 replication initiator protein RepA -
HV308_RS23895 96485..97090 - 606 WP_000509966.1 recombinase family protein -
HV308_RS23900 97185..98429 + 1245 Protein_85 Tn3-like element Tn5403 family transposase -
HV308_RS23905 98481..99185 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
HV308_RS23910 99249..99731 + 483 Protein_87 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - wbbO / wbbN / glf / wbbM / wzt / wzm / mrkA / mrkB / mrkC / mrkD / mrkF 1..142158 142158
- inside IScluster/Tn - - 93388..103869 10481


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-88)

Antitoxin

Antitoxin ParD

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11005.52 Da        Isoelectric Point: 6.2103

>T162772 WP_000277490.1 NZ_CP056149:c95014-94730 [Enterobacter roggenkampii]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL

Download         Length: 285 bp

>T162772 NZ_CP072054:3872690-3873025 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8875.01 Da        Isoelectric Point: 7.0130

>AT162772 WP_000124732.1 NZ_CP056149:c95249-95007 [Enterobacter roggenkampii]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV

Download         Length: 243 bp

>AT162772 NZ_CP072054:3872442-3872690 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F4A9

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V8C3

References