Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3886102..3886759 Replicon chromosome
Accession NZ_CP056148
Organism Enterobacter roggenkampii strain RHBSTW-00872

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag HV308_RS18800 Protein ID WP_021242050.1
Coordinates 3886102..3886512 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag HV308_RS18805 Protein ID WP_006178375.1
Coordinates 3886493..3886759 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV308_RS18780 3882095..3883828 - 1734 WP_059359737.1 single-stranded-DNA-specific exonuclease RecJ -
HV308_RS18785 3883834..3884547 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV308_RS18790 3884576..3885472 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
HV308_RS18795 3885574..3886095 + 522 WP_023309099.1 flavodoxin FldB -
HV308_RS18800 3886102..3886512 - 411 WP_021242050.1 protein YgfX Toxin
HV308_RS18805 3886493..3886759 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
HV308_RS18810 3887054..3888034 + 981 WP_008499712.1 tRNA-modifying protein YgfZ -
HV308_RS18815 3888119..3888778 - 660 WP_032664328.1 hemolysin III family protein -
HV308_RS18820 3889044..3889775 + 732 WP_059359735.1 MurR/RpiR family transcriptional regulator -
HV308_RS18825 3889892..3891325 + 1434 WP_023294510.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T162770 WP_021242050.1 NZ_CP056148:c3886512-3886102 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T162770 NZ_CP072054:3614076-3614372 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT162770 WP_006178375.1 NZ_CP056148:c3886759-3886493 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT162770 NZ_CP072054:3614374-3614769 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References