Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1058432..1059052 Replicon chromosome
Accession NZ_CP056148
Organism Enterobacter roggenkampii strain RHBSTW-00872

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag HV308_RS05120 Protein ID WP_008499287.1
Coordinates 1058432..1058650 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag HV308_RS05125 Protein ID WP_008499288.1
Coordinates 1058678..1059052 (-) Length 125 a.a.

Genomic Context


HV308_RS05090HV308_RS05095HV308_RS05105HV308_RS05130HV308_RS05135HV308_RS05140HV308_RS05100HV308_RS05110HV308_RS05115HV308_RS05120HV308_RS05125
Location: 1054445..1054705 (261 bp)
Type: Others
Protein ID: WP_006176933.1
Location: 1054708..1054848 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 1055657..1057117 (1461 bp)
Type: Others
Protein ID: WP_059359545.1
Location: 1059365..1059769 (405 bp)
Type: Others
Protein ID: WP_003031976.1
Location: 1059766..1060113 (348 bp)
Type: Others
Protein ID: WP_000612626.1
Location: 1060162..1061700 (1539 bp)
Type: Others
Protein ID: WP_048213845.1
Location: 1054845..1055555 (711 bp)
Type: Others
Protein ID: WP_059359547.1
Location: 1057089..1057556 (468 bp)
Type: Others
Protein ID: WP_008499285.1
Location: 1057674..1058225 (552 bp)
Type: Others
Protein ID: WP_008499286.1
Location: 1058432..1058650 (219 bp)
Type: Toxin
Protein ID: WP_008499287.1
Location: 1058678..1059052 (375 bp)
Type: Antitoxin
Protein ID: WP_008499288.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HV308_RS050901054445..1054705+261WP_006176933.1type B 50S ribosomal protein L31-
HV308_RS050951054708..1054848+141WP_003859006.1type B 50S ribosomal protein L36-
HV308_RS051001054845..1055555-711WP_059359547.1GNAT family N-acetyltransferase-
HV308_RS051051055657..1057117+1461WP_059359545.1PLP-dependent aminotransferase family protein-
HV308_RS051101057089..1057556-468WP_008499285.1membrane protein-
HV308_RS051151057674..1058225-552WP_008499286.1maltose O-acetyltransferase-
HV308_RS051201058432..1058650-219WP_008499287.1hemolysin expression modulator HhaToxin
HV308_RS051251058678..1059052-375WP_008499288.1Hha toxicity modulator TomBAntitoxin
HV308_RS051301059365..1059769+405WP_003031976.1IS66 family insertion sequence hypothetical protein-
HV308_RS051351059766..1060113+348WP_000612626.1IS66 family insertion sequence element accessory protein TnpB-
HV308_RS051401060162..1061700+1539WP_048213845.1IS66-like element ISKpn24 family transposase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-114)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T162759 WP_008499287.1 NZ_CP056148:c1058650-1058432 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T162759 NZ_CP072054:c1302456-1302262 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT162759 WP_008499288.1 NZ_CP056148:c1059052-1058678 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT162759 NZ_CP072054:1302085-1302263 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A1H8SI38


Antitoxin

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Source
ID
Structure
AlphaFold DBV3PBI9

References