Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1058432..1059052 Replicon chromosome
Accession NZ_CP056148
Organism Enterobacter roggenkampii strain RHBSTW-00872

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag HV308_RS05120 Protein ID WP_008499287.1
Coordinates 1058432..1058650 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag HV308_RS05125 Protein ID WP_008499288.1
Coordinates 1058678..1059052 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV308_RS05090 1054445..1054705 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
HV308_RS05095 1054708..1054848 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV308_RS05100 1054845..1055555 - 711 WP_059359547.1 GNAT family N-acetyltransferase -
HV308_RS05105 1055657..1057117 + 1461 WP_059359545.1 PLP-dependent aminotransferase family protein -
HV308_RS05110 1057089..1057556 - 468 WP_008499285.1 membrane protein -
HV308_RS05115 1057674..1058225 - 552 WP_008499286.1 maltose O-acetyltransferase -
HV308_RS05120 1058432..1058650 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
HV308_RS05125 1058678..1059052 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
HV308_RS05130 1059365..1059769 + 405 WP_003031976.1 IS66 family insertion sequence hypothetical protein -
HV308_RS05135 1059766..1060113 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
HV308_RS05140 1060162..1061700 + 1539 WP_048213845.1 IS66-like element ISKpn24 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T162759 WP_008499287.1 NZ_CP056148:c1058650-1058432 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T162759 NZ_CP072054:c1302456-1302262 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT162759 WP_008499288.1 NZ_CP056148:c1059052-1058678 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT162759 NZ_CP072054:1302085-1302263 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References