Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 128233..128993 Replicon plasmid pRHBSTW-00883_2
Accession NZ_CP056146
Organism Klebsiella variicola strain RHBSTW-00883

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV312_RS27130 Protein ID WP_049157791.1
Coordinates 128233..128718 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV312_RS27135 Protein ID WP_086070828.1
Coordinates 128706..128993 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV312_RS27085 123448..124281 - 834 WP_087846441.1 N-6 DNA methylase -
HV312_RS27090 124327..124557 - 231 WP_086070792.1 hypothetical protein -
HV312_RS27095 124645..124992 - 348 WP_023292162.1 hypothetical protein -
HV312_RS27100 125059..125439 - 381 WP_038990973.1 hypothetical protein -
HV312_RS27105 126238..126651 - 414 WP_181482143.1 helix-turn-helix domain-containing protein -
HV312_RS27110 126652..126930 - 279 WP_047722602.1 helix-turn-helix domain-containing protein -
HV312_RS27115 126920..127240 - 321 WP_086070789.1 type II toxin-antitoxin system RelE/ParE family toxin -
HV312_RS27120 127395..127607 - 213 WP_086070788.1 hypothetical protein -
HV312_RS27125 127668..127946 - 279 WP_086070787.1 hypothetical protein -
HV312_RS27130 128233..128718 - 486 WP_049157791.1 GNAT family N-acetyltransferase Toxin
HV312_RS27135 128706..128993 - 288 WP_086070828.1 DUF1778 domain-containing protein Antitoxin
HV312_RS27140 129654..131153 + 1500 WP_047666380.1 SAVED domain-containing protein -
HV312_RS27145 131159..132304 + 1146 WP_047666381.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..165251 165251


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(25-150)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17795.50 Da        Isoelectric Point: 9.4841

>T162756 WP_049157791.1 NZ_CP056146:c128718-128233 [Klebsiella variicola]
VGRVTAPEPLSTYHQVAEFVSGETVLDDWLKQKGLKNQALGAARTFVVCKKDTQQIAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQERTLFLKLP
Q

Download         Length: 486 bp

>T162756 NZ_CP072054:c1156443-1156336 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11056.76 Da        Isoelectric Point: 4.6696

>AT162756 WP_086070828.1 NZ_CP056146:c128993-128706 [Klebsiella variicola]
MLYKRCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVTDD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT162756 NZ_CP072054:1156491-1156557 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References