Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2737092..2738680 Replicon chromosome
Accession NZ_CP056145
Organism Klebsiella variicola strain RHBSTW-00883

Toxin (Protein)


Gene name hipA Uniprot ID A0A0B7G636
Locus tag HV312_RS13315 Protein ID WP_012968244.1
Coordinates 2737092..2738414 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2V3KHJ7
Locus tag HV312_RS13320 Protein ID WP_038422544.1
Coordinates 2738414..2738680 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV312_RS13300 2732157..2734658 + 2502 WP_181482062.1 fimbrial biogenesis outer membrane usher protein -
HV312_RS13305 2734646..2735650 + 1005 WP_117119170.1 type 1 fimbrial protein -
HV312_RS13310 2735783..2737075 + 1293 WP_130993736.1 glycoside hydrolase family 10 protein -
HV312_RS13315 2737092..2738414 - 1323 WP_012968244.1 type II toxin-antitoxin system HipA family toxin Toxin
HV312_RS13320 2738414..2738680 - 267 WP_038422544.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HV312_RS13325 2738946..2739272 - 327 WP_181482064.1 hydroxyisourate hydrolase -
HV312_RS13330 2739269..2739769 - 501 WP_008804922.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HV312_RS13335 2739747..2741126 - 1380 WP_148273897.1 purine permease -
HV312_RS13340 2741472..2742626 + 1155 WP_032754375.1 FAD-dependent urate hydroxylase HpxO -
HV312_RS13345 2742607..2743530 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48896.29 Da        Isoelectric Point: 7.9109

>T162751 WP_012968244.1 NZ_CP056145:c2738414-2737092 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGELMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T162751 NZ_CP072026:c1153017-1152751 [Akkermansia muciniphila]
ATGAAAAGAAATATTGTCTTTGCTCCCCAGGCATGGGAGGATTTTCAATTCTTTCTTGGCAATGACCGGAAAACCTGCAA
GCGCATCCTGGACATGATCAAGGAAATCCAGCGCACCCCGTTTGACGGGAAGGGCAAGCCGGAACCCTTGAGGGAAAACC
TTTCCGGGTTCTGGTCAAGGCGCATTGATTCAACAAACCGCCTTGTTTACCGCATCACGGAAACAGATCTAGAACTGCTT
CAAATGCGCTACCATTACGGCAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9923.30 Da        Isoelectric Point: 8.5912

>AT162751 WP_038422544.1 NZ_CP056145:c2738680-2738414 [Klebsiella variicola]
MTSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT162751 NZ_CP072026:c1153305-1153033 [Akkermansia muciniphila]
ATGAATACTATTTCAAGCACCGCCGCGCGGCAATCCATATCCAAGACGCTGGCTGCCGTCCTGAATGACCGTGAACCCGT
CCGCATTGTCAATAAACGCCTGGGGGCGGTCATCATCATGCCGGAAGATGAATTCAATTCCTGGCAGGAAACAATATATT
TGCTCAAATGTCCGGCCAATGCCCGCCGCCTGCTTGACGGCGTGGAAGCTCTCAACCGCCGTCAAGGCACGGTAACAAAG
ACCGTTGAAGAGTTGGAACATCATTCCTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7G636

Antitoxin

Source ID Structure
AlphaFold DB A0A2V3KHJ7

References