Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 808055..808712 Replicon chromosome
Accession NZ_CP056145
Organism Klebsiella variicola strain RHBSTW-00883

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HV312_RS03980 Protein ID WP_002916310.1
Coordinates 808302..808712 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HV312_RS03975 Protein ID WP_002916312.1
Coordinates 808055..808321 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV312_RS03950 804549..805277 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
HV312_RS03955 805328..805639 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
HV312_RS03960 805803..806462 + 660 WP_008806429.1 hemolysin III family protein -
HV312_RS03965 806528..806779 + 252 WP_142668898.1 hypothetical protein -
HV312_RS03970 806826..807809 - 984 WP_012967246.1 tRNA-modifying protein YgfZ -
HV312_RS03975 808055..808321 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HV312_RS03980 808302..808712 + 411 WP_002916310.1 protein YgfX Toxin
HV312_RS03985 808719..809240 - 522 WP_181481756.1 flavodoxin FldB -
HV312_RS03990 809341..810237 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
HV312_RS03995 810260..810973 + 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV312_RS04000 810979..812712 + 1734 WP_012540594.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T162742 WP_002916310.1 NZ_CP056145:808302-808712 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T162742 NZ_CP071994:810204-810566 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT162742 WP_002916312.1 NZ_CP056145:808055-808321 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT162742 NZ_CP071994:810037-810207 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References