162723

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1997701..1998227 Replicon chromosome
Accession NZ_CP056132
Organism Enterobacter hormaechei strain RHBSTW-00916

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HV326_RS09600 Protein ID WP_000323025.1
Coordinates 1997940..1998227 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag HV326_RS09595 Protein ID WP_004196370.1
Coordinates 1997701..1997940 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV326_RS09565 1993038..1993230 - 193 Protein_1857 MFS transporter -
HV326_RS09570 1993260..1994237 + 978 WP_004196334.1 chromate resistance protein -
HV326_RS09575 1994194..1995570 + 1377 WP_004196363.1 chromate efflux transporter -
HV326_RS09580 1995601..1996290 - 690 WP_004196322.1 hypothetical protein -
HV326_RS09585 1996304..1997041 - 738 WP_008460272.1 HupE/UreJ family protein -
HV326_RS09590 1997085..1997450 - 366 WP_009651956.1 hypothetical protein -
HV326_RS09595 1997701..1997940 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HV326_RS09600 1997940..1998227 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HV326_RS09605 1998329..1998454 - 126 WP_151884424.1 division septum protein Blr -
HV326_RS09610 1998694..1999734 + 1041 WP_047051384.1 oxidoreductase -
HV326_RS09615 1999791..2000789 - 999 WP_015570661.1 adenosine deaminase -
HV326_RS09620 2000886..2002058 - 1173 WP_047051382.1 pyridoxal phosphate-dependent aminotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T162723 WP_000323025.1 NZ_CP056132:1997940-1998227 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T162723 NZ_CP071981:c911410-911144 [Helicobacter pylori]
GTGTTGAAGCTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAGGAAGTCATTCTAACCTTAAGAAAGAAAGAACCGCTACCCCCACCCTTTAAAGATCACGCTTTAAAGGGGATTTGGA
AGCCTTATAGAGAATGCCACATTAAGCCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTGTTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT162723 WP_004196370.1 NZ_CP056132:1997701-1997940 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT162723 NZ_CP071981:c911756-911391 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCCAAAAACAGCTTTTTAACCTCATGAATAAAAAAGAACAAGA
AATTGAAAAGCTAAAAAGGGATAGGGTATATCTTGAAAAGAAAATGGCTAAAGAGCTAGAAAAAAAAGATAAAAGTTTTA
AAAATAAGTCAGAAGAGTTGAACAAAATCTTACAAGAGATCAACAAAAGAGCTAATGATTGTTGTTTTGGTCATGAAACC
CCAAATATTGAAACGCAACAAGCCATGAGAGAAGCGGATAACAAAGAAACAGATTTGTTCGTTGAGGATTTTTCTAGTTA
TAGCAATGAGAGAAAAAAGGCTTTAGGTGTTGAAGCTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References