Detailed information of TA system TA162721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1572240..1573153
• Replicon: chromosome
• Accession: NZ_CP056132
• Organism: Enterobacter hormaechei strain RHBSTW-00916

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HV326_RS07465
• Protein ID: WP_047052345.1
• Coordinates: 1572240..1572713 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HV326_RS07470
• Protein ID: WP_047052347.1
• Coordinates: 1572710..1573153 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV326_RS07445	1568399..1569709	+	1311	WP_047052339.1	type I-F CRISPR-associated protein Csy1	-
HV326_RS07450	1569706..1570641	+	936	WP_047052340.1	type I-F CRISPR-associated protein Csy2	-
HV326_RS07455	1570655..1571653	+	999	WP_047052342.1	type I-F CRISPR-associated protein Csy3	-
HV326_RS07460	1571663..1572217	+	555	WP_047052344.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
HV326_RS07465	1572240..1572713	-	474	WP_047052345.1	RES domain-containing protein	Toxin
HV326_RS07470	1572710..1573153	-	444	WP_047052347.1	DUF2384 domain-containing protein	Antitoxin
HV326_RS07475	1575045..1575263	-	219	WP_002211347.1	translation initiation factor IF-1	-
HV326_RS07480	1575548..1576252	-	705	WP_047052381.1	leucyl/phenylalanyl-tRNA--protein transferase	-
HV326_RS07485	1576298..1578019	-	1722	WP_181522485.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-144)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17570.95 Da
• Isoelectric Point: 5.1151

>T162721 WP_047052345.1 NZ_CP056132:c1572713-1572240 [Enterobacter hormaechei]
MIFYRLVTGRFASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSINIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPAFRKALNSVELLPFDFDTRLAEKTAP

Nucleotide

• Length: 474 bp

>T162721 NZ_CP071978:c933679-933413 [Helicobacter pylori]
GTGTTGAAGCTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGTGTTTT
GAAGGAAGTCATTCTAACCTTGAGAAAGAAAGAACCACTACCCCCACCATTTAAAGATCACGCTTTAAAGGGGATTTGGA
AGCCTTATAGAGAATGCCACATTAAGCCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTGTTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16502.77 Da
• Isoelectric Point: 6.4819

>AT162721 WP_047052347.1 NZ_CP056132:c1573153-1572710 [Enterobacter hormaechei]
MRTWVPAQRSADNTLWRYAGLPASRGMRLIEYLNQGLPVSVLDNIHEWTDMSKAEILRVTGINERNVARRKSTGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQLPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT162721 NZ_CP071978:c934025-933660 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGACTACACAAAATACAGCCAAAGACAGCTTTTTAACCTCATGAATAAAAAAGAACAAGA
AATTGAAAAGCTAAAAAGGGATAGGGCGTATCTTGAAAAGAAAATGGCTAAAGAGCTAGAAAAAAAAGATAAAGGTTTCA
CTATCAAGTTAGAAGAATTGAACAAAATCTTACAAGAGATCAACAAAAGAGCTAATGATTGTTGTTTTGGGCATGAAACC
CCAAACATTCAAACGCAACAAGCCATGAGAGAAGCGGATAACAAAGAAACAGATTTGTTCGTTGAGGATTTTTCTAGTTA
TAGTAATGAGAGAAAAAAGGCTTTAGGTGTTGAAGCTCAACCTTAA