Detailed information of TA system TA162719

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 980628..981337
• Replicon: chromosome
• Accession: NZ_CP056132
• Organism: Enterobacter hormaechei strain RHBSTW-00916

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A7D6YAQ1
• Locus tag: HV326_RS04700
• Protein ID: WP_071886833.1
• Coordinates: 980969..981337 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV326_RS04695
• Protein ID: WP_047051179.1
• Coordinates: 980628..980948 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV326_RS04655	976188..977022	+	835	Protein_897	DUF945 domain-containing protein	-
HV326_RS04660	977224..977928	+	705	WP_047051185.1	WYL domain-containing protein	-
HV326_RS04665	977925..978539	+	615	WP_047051184.1	hypothetical protein	-
HV326_RS04670	978628..979038	+	411	WP_047051183.1	hypothetical protein	-
HV326_RS04675	979115..979351	+	237	WP_047051182.1	DUF905 domain-containing protein	-
HV326_RS04680	979431..979889	+	459	WP_047051181.1	antirestriction protein	-
HV326_RS04685	979898..980380	+	483	WP_075211782.1	DNA repair protein RadC	-
HV326_RS04690	980389..980610	+	222	WP_016243789.1	DUF987 domain-containing protein	-
HV326_RS04695	980628..980948	+	321	WP_047051179.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV326_RS04700	980969..981337	+	369	WP_071886833.1	TA system toxin CbtA family protein	Toxin
HV326_RS04705	981683..982429	-	747	WP_047051178.1	class I SAM-dependent methyltransferase	-
HV326_RS04710	982440..982697	-	258	WP_003863178.1	YjhX family toxin	-
HV326_RS04715	982957..984894	-	1938	WP_047051177.1	bifunctional diguanylate cyclase/phosphodiesterase	-
HV326_RS04720	984912..985406	-	495	WP_047051176.1	oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	957399..981337	23938

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (6-105)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13738.90 Da
• Isoelectric Point: 8.1347

>T162719 WP_071886833.1 NZ_CP056132:980969-981337 [Enterobacter hormaechei]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKYELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ

Nucleotide

• Length: 369 bp

>T162719 NZ_CP071977:c920821-920555 [Helicobacter pylori]
GTGTTGAAGCTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAGGAAGTCATTCTAACCTTGAGGAAGAAAGAACCGCTACCCCCACCATTTAAAGATCACGCTTTAAAGGGGATTTGGA
AGCCTTATAGAGAATGCCACATTAAGCCTGGTATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTGTTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11901.60 Da
• Isoelectric Point: 7.2633

>AT162719 WP_047051179.1 NZ_CP056132:980628-980948 [Enterobacter hormaechei]
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISLMESMLTTGEMNPRHAHCVTLY
RNGFTCEADTLGSCGYLYIVVYPTQS

Nucleotide

• Length: 321 bp

>AT162719 NZ_CP071977:c921167-920802 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGACTACACAAAATACAGCCAAAGACAGCTTTTTAACCTCATGAATAAAAAAGAACAAGA
AATTGAAAAGCTAAAAAGGGATAGGGCGTATCTTGAAAAGAAAATGGCTAAAGAGCTAGAAAAAAAAGATAAAGGTTTCA
CTATCAAGTTAGAAGAATTGAACAAAATCTTACAAGAGATCAACAAAAGAGCTAATGATTGTTGTTTTGGGCATGAAACC
CCAAACATTCAAACGCAACAAGCCATGAGAGAAGCGGATAACAAAGAAACAGATTTGTTCGTTGAGGATTTTTCTAGTTA
TAGCAATGAAAGAAAAAAGGCTTTAGGTGTTGAAGCTCAATCTTAA

Structures

Toxin

• AlphaFold DB: A0A7D6YAQ1