Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 310545..311141 Replicon chromosome
Accession NZ_CP056132
Organism Enterobacter hormaechei strain RHBSTW-00916

Toxin (Protein)


Gene name PumA Uniprot ID A0A837F9W8
Locus tag HV326_RS01495 Protein ID WP_023315213.1
Coordinates 310839..311141 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837FG03
Locus tag HV326_RS01490 Protein ID WP_022650216.1
Coordinates 310545..310832 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV326_RS01485 308917..310548 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
HV326_RS01490 310545..310832 - 288 WP_022650216.1 putative addiction module antidote protein Antitoxin
HV326_RS01495 310839..311141 - 303 WP_023315213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV326_RS01500 311339..312211 + 873 WP_022646725.1 23S rRNA pseudouridine(2604) synthase RluF -
HV326_RS01505 312212..312484 - 273 WP_047052050.1 DUF3811 domain-containing protein -
HV326_RS01510 312535..313479 - 945 WP_032627014.1 ketopantoate/pantoate/pantothenate transporter PanS -
HV326_RS01515 313573..314922 - 1350 WP_045344657.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.21 Da        Isoelectric Point: 10.1042

>T162718 WP_023315213.1 NZ_CP056132:c311141-310839 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T162718 NZ_CP071977:c920821-920555 [Helicobacter pylori]
GTGTTGAAGCTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAGGAAGTCATTCTAACCTTGAGGAAGAAAGAACCGCTACCCCCACCATTTAAAGATCACGCTTTAAAGGGGATTTGGA
AGCCTTATAGAGAATGCCACATTAAGCCTGGTATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTGTTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10087.57 Da        Isoelectric Point: 5.7807

>AT162718 WP_022650216.1 NZ_CP056132:c310832-310545 [Enterobacter hormaechei]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT162718 NZ_CP071977:c920507-920256 [Helicobacter pylori]
ATGCCTAACACCACCAAAAAAGATTACACAAAATACAGCCAAAAACAGCTTTTTAATCTCATTAATCAATTAGAGCAAAA
AATCAGCCAAGCTTTTGATGATAAAAGAGGTTGTTGTTTGGGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATAA
GAGGTGCGTTAAATGGCGAAAATTTAGAAACTATTGAAGATTTTTCTGCATGGACCAATGAAAGAAAAAAGGAAGTGAAT
GCTGAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F9W8

Antitoxin

Source ID Structure
AlphaFold DB A0A837FG03

References