Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 862545..863202 Replicon chromosome
Accession NZ_CP056129
Organism Enterobacter roggenkampii strain RHBSTW-00925

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag HV328_RS04165 Protein ID WP_021242050.1
Coordinates 862792..863202 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag HV328_RS04160 Protein ID WP_006178375.1
Coordinates 862545..862811 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV328_RS04140 858288..859304 + 1017 WP_148933803.1 IS5-like element IS5 family transposase -
HV328_RS04145 859529..860260 - 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
HV328_RS04150 860526..861185 + 660 WP_047745991.1 hemolysin III family protein -
HV328_RS04155 861270..862250 - 981 WP_047745992.1 tRNA-modifying protein YgfZ -
HV328_RS04160 862545..862811 + 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
HV328_RS04165 862792..863202 + 411 WP_021242050.1 protein YgfX Toxin
HV328_RS04170 863209..863730 - 522 WP_008499710.1 flavodoxin FldB -
HV328_RS04175 863832..864728 + 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
HV328_RS04180 864757..865470 + 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV328_RS04185 865476..867209 + 1734 WP_181519140.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 858324..859304 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T162699 WP_021242050.1 NZ_CP056129:862792-863202 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T162699 NZ_CP071956:c7015-6722 [Xanthomonas fragariae]
GTGCCACACGTAATCATCACGGAAGGCGCAGGCCAAGGATTGGAGTGCTGCCGGCGCTTTTTGGCCAGTAAAAGTCCGGA
AGCAGCCCGGCGAGCCGCAAAGGCCATCGAGCGGCAATTCCTGTTGCTGGAAACGACCCCGGCCATCGGCCGCCCTTTTT
CCGAGCAACCGGAGTGGAGCGAGTTGGTCATCGAATTCGGTGATTCCGGCTATGTAGCCTTGTATCGCCACGAAGCTGCA
GAGGATGTCGTTTACGTGCTGGCTTTCCGACATCAGAAGGAAGTGGGATATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT162699 WP_006178375.1 NZ_CP056129:862545-862811 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT162699 NZ_CP071956:c7275-7003 [Xanthomonas fragariae]
ATGGCAACGTCACTAAAAATCGACGACGAGCTGAAGGGGCGCGTGCAGCACCTGGCCAGCCTGCGCGATCGGTCGCCACA
CTGGATCATGCGTGAAGCGATCAAGCAGTACGTGGAGCTGGAAGAAGCTCGCGAAAGTTTTAAGCAGGAAGCGCAGGCAT
CCTGGATCGCCTATCAGGAAACCGGCCGGCATTTGACCGGGCAGGAGGCGCGCGCGTGGTTGAACACCTGGGGCACGGAC
AACGAAACGGGTTTGCCTGAGTGCCACACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References